P-Fimbriae: Molecular Aspects of their Structure and their Application as Carriers of Foreign Antigenic Determinants

  • Irma van Die
  • Nico Riegman
  • Joost van Oosterhout
  • Hans Bergmans
  • Anneke van der Zee
  • Hanneke Bes
  • Wiel Hoekstra
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 51)


Urinary tract infections (UTI) are often caused by Escherichia coli. Properties associated with virulence include certain 0- and K-antigens, P-fimbriae, production of hemolysin or colicin and resistance to serum bactericidal activity. Adherence of the bacteria to the uroepithelium is considered to be an important initial event in the pathogenesis of UTI. Adherence and the ability to cause mannose-resis-tant hemagglutination of human erythrocytes are associated in most UTI strains with the presence of P-fimbriae (1). Pfimbriae, or pap-pili, belong to a widely occurring family of fimbriae, filamentous surface components composed of ä thousand protein subunits (for a review see 2). P-fimbriae specifically recognize the α -DGal(1–3) β -DGal moiety of glycolipids, which is also part of the P-blood group antigens (3, 4). Among P-fimbriae a number of different serotypes are discriminated, designated as F7–F14 (5).


Hypervariable Region Major Subunit Hypervariable Region Serum Bactericidal Activity Fimbrial Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Vaisanen, V., Elo, J., Tallgren, L.G., Siitonen, A., Makela, P.H., Svanborg-Eden, C., Kallenius, G., Svenson, S.B., Hultberg, H., and Korhonen, T.K. 1981. Lancet ii: 1366–1369.CrossRefGoogle Scholar
  2. 2.
    Klemm, P. 1985. Rev. Infect. Dis. 7:321–340.PubMedCrossRefGoogle Scholar
  3. 3.
    Kallenius, G., Svensson, S.B., Mollby, R., Cedergren, B., Hultberg, H., and Winberg, J. 1981. Lancet ii:604–606.CrossRefGoogle Scholar
  4. 4.
    Leffler, H. and Svanborg-Eden, C. 1980. FEMS Microbiol. Lett. 8:127–134.CrossRefGoogle Scholar
  5. 5.
    Orskov, I. and Orskov, F. 1985. J. Hyg.95:551–575.CrossRefGoogle Scholar
  6. 6.
    Hull, R.A., Gill, R.E., Hsu, P., Minshew, B.H., and Falkow, S. 1981. Infect. Immun. 33:933–938.PubMedGoogle Scholar
  7. 7.
    Van Die, I., Van den Hondel, C., Hcimstra, H.J., Hoekstra, W. and Bergmans, H. 1983. FEMS Microbiol. Lett. 19:77–82.CrossRefGoogle Scholar
  8. 8.
    Van Die, I., Spierings, G., Van Megen, I., Zuidweg, E., Hoekstra, W. and Bergmans, H. 1985. FEMS Microbiol. Lett. 28:329–334.CrossRefGoogle Scholar
  9. 9.
    De Ree, J.M., Schwillens, P. and Van den Bosch, J.F. 1985. FEMS Microbiol. Lett. 29:91–97.Google Scholar
  10. 10.
    Norgren, M., Normark, S., Lark, D., O’Hanley, P., Schoolnik, G., Falkow, S., Svanborg-Eden, C., Baga, M., and Uhlin, B.E. 1984. EMBO J. 3:1159–1169.PubMedGoogle Scholar
  11. 11.
    Van Die, I., Van Megen, I., Hoekstra, W. and Bergmans, H. 1984. Mol. Gen. Genet. 194:528–533.PubMedCrossRefGoogle Scholar
  12. 12.
    Lindberg, F.P., Lund, B., Johansson, L. and Normark, S. 1987. Nature London. 328:84–87.PubMedCrossRefGoogle Scholar
  13. 13.
    Van Die, I., Van Megen, I., Zuidweg, E., Hoekstra, W., De Ree, H., Van den Bosch, H. and Bergmans, H. 1986. J. Bacterid. 167:407–410.Google Scholar
  14. 14.
    Lund, B., Lindberg, F., Marklund, B.I., Normark, S. 1987. Proc. Natl. Acad. Sci. USA 84:5898–5902.PubMedCrossRefGoogle Scholar
  15. 15.
    Van Bergenen Henegouwen, P.M.P. and Leunissen, J.L.M. 1986. Histochem. 85:81–87.Google Scholar
  16. 16.
    Abraham, S.N., Goguen, J.D., Sun, D., Klemm, P., and Beachey, E.H. 1987. J. Bacteriol. 169:5530–5536.PubMedGoogle Scholar
  17. 17.
    Abraham, S.N., Goguen, J.D., and Beachey, E.H. 1988. Infect. Immun. 56:1023–1029.PubMedGoogle Scholar
  18. 18.
    Krogfelt, K.A. and Klemm, P. 1988. Microb. Pathogen. 4: 231–238.CrossRefGoogle Scholar
  19. 19.
    Van Die, I., Hoekstra, W., and Bergmans, H. 1987. Microb. Pathogen. 3:149–154.CrossRefGoogle Scholar
  20. 20.
    Van Die, I., Riegman, N., Gaykema, O., Van Megen, I., Hoekstra, W., Bergmans, H., De Ree, H. and Van den Bosch, H. 1988. FEMS Microbiol. Lett. 49:95–100.CrossRefGoogle Scholar
  21. 21.
    Korhonen, T.K., and Rhen, M. 1982. Ann. Clin. Res. 14:272–277.PubMedGoogle Scholar
  22. 22.
    Van Die, I., Wauben, M., Van Megen, I., Bergmans, H., Riegman, N., Hoekstra, W., Pouwels, P., and Enger-Valk, B. 1988. J. Bacteriol. 170:5870–5876.PubMedGoogle Scholar
  23. 23.
    Meloen, R.H, Puijk, W.C., Meijer, D.J.A., Lankhof, H., Posthumus, W.P.A., and Schaaper, W.M.M. 1987. J. Gen. Virol. 68:305–314.PubMedCrossRefGoogle Scholar
  24. 24.
    Dougan, G., Hormaeche, C.E., Maskell, D.J. 1987. Parasite Immunol. 9:151–160.PubMedCrossRefGoogle Scholar
  25. 25.
    Stevenson, G. and Manning, P. 1985. FEMS Microbiol. Lett. 28:317–321.CrossRefGoogle Scholar
  26. 26.
    De Ree, J.M., Schwillens, P., and Van den Bosch, J.F. 1985. Infect. Immun. 50:900–904.Google Scholar
  27. 27.
    Hoschutzky, H., Lottspeich, F. and Jann, K. 1989. Infect. Immun. 57:76–81.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Irma van Die
    • 1
  • Nico Riegman
    • 1
  • Joost van Oosterhout
    • 1
  • Hans Bergmans
    • 1
  • Anneke van der Zee
    • 1
  • Hanneke Bes
    • 1
  • Wiel Hoekstra
    • 1
  1. 1.Department of Molecular Cell BiologyUtrechtThe Netherlands

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