Studies on the Genetic Basis of Haemophilus Influenzae Pathogenicity

  • E. Richard Moxon
  • Jeffrey N. Weiser
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 51)


The pathogenesis of bacterial meningitis comprises a sequence of several distinct events; acquisition of the causative bacterium from another individual, colonization, invasion of mucosal epithelium resulting in bacteremia, haematogenous dissemination, invasion of the blood-brain barrier and, finally, the occurrence of inflammatory changes within the subarachnoid space consequent upon bacterial multiplication within the central nervous system (Figure 1).


Bacterial Meningitis Haemophilus Influenzae Influenzae Strain United Kingdom Introduction Intranasal Challenge 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • E. Richard Moxon
    • 1
  • Jeffrey N. Weiser
    • 2
  1. 1.Molecular Infectious Diseases GroupOxford UniversityHeadington, OxfordUK
  2. 2.Department of Paediatrics, Institute of Molecular MedicineJohn Radcliffe HospitalHeadington, OxfordUK

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