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Genetics of Factors Involved in Extraintestinal E. Coli Pathogenicity

  • Jörg Hacker
  • Reinhard Marre
  • Joachim Morschhäuser
  • Manfred Ott
  • Thomas Schmoll
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 51)

Abstract

Escherichia coli strains may cause urinary tract infections (UTI), sepsis and cases of new born meningitis (NBM). It has been shown that different factors contribute to pathogenicity of extraintestinal E. coli strains. Certain types of O antigen (01, 02, 018, 075) and capsule (K1, K5, K15) are necessary for resistance of pathogens to the action of the immune system especially to lysis of serum complement compounds (1). Siderophore systems like aerobactin molecules are able to take up iron from the environment of the strains and they support extraintestinal E, coli with these ions (2). Hemolysins represent protein toxins which are able to disrupt eukaryotic cells (3). Under sublethal concentrations hemolysin proteins stimulate the release of mediators of inflammation from leukocytes and mast cells (4).

Keywords

Major Subunit Urinary Tract Infec Sialic Acid Binding Fimbrial Adhesin Pathogenicity Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Jörg Hacker
    • 1
  • Reinhard Marre
    • 2
  • Joachim Morschhäuser
    • 1
  • Manfred Ott
    • 1
  • Thomas Schmoll
    • 1
  1. 1.Insitut für Genetik und MikrobiologieUniv. WürzburgWürzburgGermany
  2. 2.Institut für Medizinische MikrobiologieUniv. LübeckLübeckGermany

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