Genetics of Factors Involved in Extraintestinal E. Coli Pathogenicity

  • Jörg Hacker
  • Reinhard Marre
  • Joachim Morschhäuser
  • Manfred Ott
  • Thomas Schmoll
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 51)


Escherichia coli strains may cause urinary tract infections (UTI), sepsis and cases of new born meningitis (NBM). It has been shown that different factors contribute to pathogenicity of extraintestinal E. coli strains. Certain types of O antigen (01, 02, 018, 075) and capsule (K1, K5, K15) are necessary for resistance of pathogens to the action of the immune system especially to lysis of serum complement compounds (1). Siderophore systems like aerobactin molecules are able to take up iron from the environment of the strains and they support extraintestinal E, coli with these ions (2). Hemolysins represent protein toxins which are able to disrupt eukaryotic cells (3). Under sublethal concentrations hemolysin proteins stimulate the release of mediators of inflammation from leukocytes and mast cells (4).


Major Subunit Urinary Tract Infec Sialic Acid Binding Fimbrial Adhesin Pathogenicity Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Orskov, I., Orskov, F., Jann, B., and Jann, K. 1976. Bacteriol. Rev. 41:667–710.Google Scholar
  2. 2.
    Bagg, A., and Neilands, J.B. 1987. Microbiol. Rev. 51: 509–534.PubMedGoogle Scholar
  3. 3.
    Hacker, J., and Hughes, C. 1985. Curr. Top. Microbiol. Immunol. 118:139–162.PubMedCrossRefGoogle Scholar
  4. 4.
    König, B., König, W., Scheffer, J., Hacker, J., and Goebel, W. 1986. Infect. Immun. 54:886–892.PubMedGoogle Scholar
  5. 5.
    Orskov, I., and Orskov, F. 1983. Prog. Allergy 33, 80–105.PubMedGoogle Scholar
  6. 6.
    Korhonen, T. K., Vaisanen-Rhen, V., Rhen, M., Pere, A., Parkkinen, J. and Finne, J. 1984. J. Bacterid. 159: 762–766.Google Scholar
  7. 7.
    Ott, M., Hacker, J., Schmoll, T., Jarchau, T., Korhonen, T.K., and Goebel, W. 1986. Infect. Immun. 54:646–653.PubMedGoogle Scholar
  8. 8.
    Hacker, J., Schmidt, G., Hughes, C., Knapp, S., Marget, M., and Goebel, W. 1985. Infect. Immun. 47:434–440.PubMedGoogle Scholar
  9. 9.
    Schmoll, T., Hacker, J., and Goebel, W. 1987. FEMS Microbiol. Lett. 41:229–235.CrossRefGoogle Scholar
  10. 10.
    Schmoll, T., Hoschutzky, H., Morschhauser, J., Lottspeich, F., Jann, K. and Hacker, J. 1989. Mol. Microbiol. 3:1735–1744.PubMedCrossRefGoogle Scholar
  11. 11.
    Moch, T., Hoschutzky, H., Hacker, J., Kroke, K.-D., Jann, K. 1987. Proc. Natl. Acad. Sci. USA 84:3462–3466.PubMedCrossRefGoogle Scholar
  12. 12.
    Klemm, P. 1985. Rev. Infect. Dis. 7:321–340.PubMedCrossRefGoogle Scholar
  13. 13.
    Jacobs, A.A.C. 1987. Structure — function relationships of the K88 and K99 fibrillar adhesins of enterotoxigenic Escherichia coli. Diss. Univ. AmsterdamGoogle Scholar
  14. 14.
    Hacker, J. Jarchau, T., Knapp, S., Marre, R., Schmidt, G., Schmoll, T., and Goebel, W. 1986. In: Protein-Carbohydrate interactions — Molecular biology of microbial pathogenicity eds: D. Lark, S. Normark, H. Wolfwatz, B.E. Uhlin., Academic Press, London pp. 125–133.Google Scholar
  15. 15.
    Schmoll, T., Morschhauser, J., Ott, M., Luderiz, B., Van Die, I. and Hacker, J. 1990. Microb. Pathogen. 9: in press.Google Scholar
  16. 16.
    Miller, V.L., Taylor, R.K., and Mekalanos, J.J. 1987. Cell 48:271–279.PubMedCrossRefGoogle Scholar
  17. 17.
    Schmoll, T., Ott, M., Oudega, B. and Hacker, J. 1989. J. Bacterid. 172:5103–5111.Google Scholar
  18. 18.
    Marre, R., Hacker, J., Henkel, W., and Goebel, W. 1986. Infect. Immun. 54:761–767.PubMedGoogle Scholar
  19. 19.
    Knapp, S., Hacker, J., Jarchau, T., and Goebel, W. 1986. J. Bacterid. 168:22–30.Google Scholar
  20. 20.
    Hacker, J., Schmoll, T., Ott, M., Marre, R., Hof, H., Jarchau, T., Knapp, S., Then, I., and Goebel, W. 1989. Stud. Iknfect. Dis. Res. eds:E. Kass and C. Svanborg-Eden, Univ. Chicago Press, Chicago, London pp.140–156.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Jörg Hacker
    • 1
  • Reinhard Marre
    • 2
  • Joachim Morschhäuser
    • 1
  • Manfred Ott
    • 1
  • Thomas Schmoll
    • 1
  1. 1.Insitut für Genetik und MikrobiologieUniv. WürzburgWürzburgGermany
  2. 2.Institut für Medizinische MikrobiologieUniv. LübeckLübeckGermany

Personalised recommendations