Urinary Glycosaminoglycan Excretion in Patients with Urolithiasis
Present evidence based on the physicochemical properties and distribution of glycosaminoglycans suggest that these compounds may play an important role in urolithiasis. Although the organic matrix of stones is not known to contain appreciable amounts of glycosaminoglycans1, it has been suggested that glycosaminoglycans and, in particular, the degree of sulphation of the molecules, may be a regulating factor in the initiation or development of calculi2. Both natural and commercially prepared glycosaminoglycans in vitro have been shown to be powerful inhibitors of calcium oxalate crystal formation and growth3,4.Urine contains several types of glycosaminoglycans, the predominant class being chondroitin sulphates A and C. Undoubtedly, the so called inhibitory power of urine is to some degree associated with these polyanionic substances4. The true potential of the compounds however, may be subject to modification by some other urinary components, for example, urates5.
KeywordsCitrate Oxalate Glycosaminoglycan
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