Studies on Inhibitors and Promoters of the Crystallization of Calcium Oxalate in Urine and in Matrix from Calcium Oxalate Stones
Urine contains some potent inhibitors of the crystal growth and/or aggregation of calcium oxalate crystals. The present concensus is that the main ones lie in the macromolecular fraction of urine1–6.Only a small fraction of calcium oxalate inhibitory activity appears to be due to small ions7 such as magnesium, pyrophosphate and citrate. The high molecular weight inhibitors appear to be acidic glycosaminoglycans (GAGS)1,3,5,acidic peptides or an RNA-like compound6. Some workers claim that stone-formers have less net inhibitory activity in their urine than normal subjects8,9,10.
KeywordsAlcian Blue Calcium Oxalate Calcium Oxalate Crystal Calcium Oxalate Stone Weight Inhibitor
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