Urolithiasis pp 601-605 | Cite as

Studies on Inhibitors and Promoters of the Crystallization of Calcium Oxalate in Urine and in Matrix from Calcium Oxalate Stones

  • D. S. Scurr
  • C. M. Bridge
  • W. G. Robertson


Urine contains some potent inhibitors of the crystal growth and/or aggregation of calcium oxalate crystals. The present concensus is that the main ones lie in the macromolecular fraction of urine1–6.Only a small fraction of calcium oxalate inhibitory activity appears to be due to small ions7 such as magnesium, pyrophosphate and citrate. The high molecular weight inhibitors appear to be acidic glycosaminoglycans (GAGS)1,3,5,acidic peptides or an RNA-like compound6. Some workers claim that stone-formers have less net inhibitory activity in their urine than normal subjects8,9,10.


Alcian Blue Calcium Oxalate Calcium Oxalate Crystal Calcium Oxalate Stone Weight Inhibitor 
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  1. 1.
    W. G. Robertson, C. F. Knowles, and M. Peacock, in: “Urolithiasis Research,” H. Fleisch, W. G. Robertson, L. H. Smith and W. Vahlensieck, eds., Plenum Press, New York (1976).Google Scholar
  2. 2.
    W. B. Gill, J. W. Karesh, L. Garsin, and M. J. Roma, Invest. Urol. 15:95 (1977).PubMedGoogle Scholar
  3. 3.
    G. L. Gardner and R. H. Doremus, Invest. Urol. 15:478 (1978).PubMedGoogle Scholar
  4. 4.
    H. Ito and F. L. Coe, Amer. J. Physiol. 233:F455 (1977).PubMedGoogle Scholar
  5. 5.
    J. D. Sallis and M. F. Lumley, Invest. Urol. 16:296 (1979).PubMedGoogle Scholar
  6. 6.
    E. E. Schrier, K. E. Lee, J. L. Rubin, P. G. Werness, and L. H. Smith, in: “Oxalate in Human Biochemistry and Clinical Pathology,” G. A. Rose, W. G. Robertson, R. W. E. Watts, eds., Wellcome Foundation, London (1980).Google Scholar
  7. 7.
    W. G. Robertson, M. Peacock, and F. Knowles, in: “Urinary Calculi,” L. Cifuentes-Delatte, A. Rapado, and A. Hodgkinson, eds., Karger, Basel (1973).Google Scholar
  8. 8.
    W. G. Robertson, M. Peacock, R. W. Marshall, D. H. Marshall, and B. E. C. Nordin, N. Eng. J. Med. 294:249 (1976).CrossRefGoogle Scholar
  9. 9.
    F. L. Coe, H. C. Margolis, L. H. Deutsch, and A. L. Straus, Mineral Electrolyte Metab. 3:268 (1980).Google Scholar
  10. 10.
    A. Ligabue, M. Fini, and W. G. Robertson, Clin. Chim. Acta. 98:39 (1979).PubMedCrossRefGoogle Scholar
  11. 11.
    W. G. Robertson and M. Peacock, Clin. Sci. 43:499 (1972).PubMedGoogle Scholar
  12. 12.
    W. H. Boyce and J. S. King, Ann. N. Y. Acad. Sci. 104:563 (1963).PubMedCrossRefGoogle Scholar
  13. 13.
    P. C. Hallson and G. A. Rose, Lancet 1:1000 (1979).PubMedCrossRefGoogle Scholar
  14. 14.
    J. E. Scott and D. J. Newton, Connect. Tiss. Res. 3:157 (1975).CrossRefGoogle Scholar
  15. 15.
    W. G. Robertson, D. S. Curr, and C. M. Bridge, J. Cryst. Growth (in press).Google Scholar
  16. 16.
    J. C. Gjaldbaek and W. G. Robertson, Clin. Chim. Acta (in press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • D. S. Scurr
    • 1
  • C. M. Bridge
    • 1
  • W. G. Robertson
    • 1
  1. 1.M.R.C. Mineral Metabolism UnitThe General InfirmaryLeedsUK

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