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Urolithiasis pp 589-599 | Cite as

Inhibitors of Calcium Oxalate and Calcium Phosphate Crystal Formation in Urine — A Critique and Reappraisal

  • P. C. Hallson
  • G. Alan Rose
  • C. T. Samuell

Abstract

Previous studies of the role of inhibitors of calcium oxalate and calcium phosphate crystal formation in urine have usually been performed either in relatively simple aqueous solutions or by addition of dilute urine samples to solutions supersaturated for calcium oxalate or phosphate1–4. These experiments however are open to serious objections: 1) Urine contains macromolecular promoters of crystal formation, probably uromucoids5, which should be included but have previously been excluded, and 2) the effect of certain inhibitors, notably pyrophosphate, citrate and methylene blue on calcium oxalate and calcium phosphate crystal formation is much less in whole urine than in simple inorganic solutions6. Even the studies of whole urine have not been physiological because they relied on addition of calcium and oxalate (or phosphate) to urine and this procedure can lead to abnormal crystal habits7.

Keywords

Methylene Blue Chondroitin Sulphate Crystal Formation Calcium Oxalate Calcium Oxalate Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • P. C. Hallson
    • 1
  • G. Alan Rose
    • 1
  • C. T. Samuell
    • 1
  1. 1.St. Peter’s Hospitals and Institute of UrologyLondonEngland

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