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Urolithiasis pp 569–577Cite as

The Sources of Phosphocitrate and its Role as an Inhibitor of Calcium Phosphate and Calcium Oxalate Crystallization

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Abstract

Earlier studies reported by Howard1 and Lehninger2 suggested that a substance containing Pi and citrate, and tentatively assigned the structure of phosphocitrate, existed in nature and was a potent inhibitor of hydroxyapatite (HAP) formation. These observations led us to attempt to isolate and characterize phosphocitrate from biological sources with a view to defining a physiological role for this compound in calcification systems.

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References

  1. J. E. Howard, Johns Hopkins Med. J. 139:239 (1976).

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  2. A. L. Lehninger, Horiz. Biochem. Biophys. 4:1 (1977).

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  3. G. Williams and J. D. Sallis, Anal. Biochem. 102:365 (1980).

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  5. G. Williams, E. S. Holdsworth and J. D. Sallis, Clin. Exp. Pharm. Physiol, (in press).

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Tasmania, Hobart, Tasmania, Australia

    G. Williams & J. D. Sallis

Authors
  1. G. Williams
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  2. J. D. Sallis
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Editor information

Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  2. The General Infirmary, Leeds, England

    William G. Robertson

  3. University of Florida, Gainesville, Florida, USA

    Birdwell Finlayson

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© 1981 Springer Science+Business Media New York

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Williams, G., Sallis, J.D. (1981). The Sources of Phosphocitrate and its Role as an Inhibitor of Calcium Phosphate and Calcium Oxalate Crystallization. In: Smith, L.H., Robertson, W.G., Finlayson, B. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8977-4_93

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  • DOI: https://doi.org/10.1007/978-1-4684-8977-4_93

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8979-8

  • Online ISBN: 978-1-4684-8977-4

  • eBook Packages: Springer Book Archive

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