Urolithiasis pp 569-577 | Cite as

The Sources of Phosphocitrate and its Role as an Inhibitor of Calcium Phosphate and Calcium Oxalate Crystallization

  • G. Williams
  • J. D. Sallis


Earlier studies reported by Howard1 and Lehninger2 suggested that a substance containing Pi and citrate, and tentatively assigned the structure of phosphocitrate, existed in nature and was a potent inhibitor of hydroxyapatite (HAP) formation. These observations led us to attempt to isolate and characterize phosphocitrate from biological sources with a view to defining a physiological role for this compound in calcification systems.


Calcium Oxalate Amorphous Calcium Phosphate Organic Phosphate Calcium Oxalate Crystal Calcium Oxalate Crystallization 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • G. Williams
    • 1
  • J. D. Sallis
    • 1
  1. 1.Department of BiochemistryUniversity of TasmaniaHobartAustralia

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