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Urolithiasis pp 569-577 | Cite as

The Sources of Phosphocitrate and its Role as an Inhibitor of Calcium Phosphate and Calcium Oxalate Crystallization

  • G. Williams
  • J. D. Sallis

Abstract

Earlier studies reported by Howard1 and Lehninger2 suggested that a substance containing Pi and citrate, and tentatively assigned the structure of phosphocitrate, existed in nature and was a potent inhibitor of hydroxyapatite (HAP) formation. These observations led us to attempt to isolate and characterize phosphocitrate from biological sources with a view to defining a physiological role for this compound in calcification systems.

Keywords

Calcium Oxalate Amorphous Calcium Phosphate Organic Phosphate Calcium Oxalate Crystal Calcium Oxalate Crystallization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J. E. Howard, Johns Hopkins Med. J. 139:239 (1976).PubMedGoogle Scholar
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    A. L. Lehninger, Horiz. Biochem. Biophys. 4:1 (1977).PubMedGoogle Scholar
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    G. Williams and J. D. Sallis, Anal. Biochem. 102:365 (1980).PubMedCrossRefGoogle Scholar
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    G. B. Jones, Anal. Biochem. 21:286 (1967).PubMedCrossRefGoogle Scholar
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    G. Williams, E. S. Holdsworth and J. D. Sallis, Clin. Exp. Pharm. Physiol, (in press).Google Scholar
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    G. Williams and J. D. Sallis, Biochem. J. 184:181 (1979).PubMedGoogle Scholar
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    S. T. Ohnishi, Anal. Biochem. 86:201 (1978).PubMedCrossRefGoogle Scholar
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    H. H. Donaldson, Am. J. Anat. 26:237 (1920).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • G. Williams
    • 1
  • J. D. Sallis
    • 1
  1. 1.Department of BiochemistryUniversity of TasmaniaHobartAustralia

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