Urolithiasis pp 539-544 | Cite as

Rates and Mechanisms of Dissolution of Renal Calculi. I. Rates and Mechanism of Dissolution of Pure Calcium Oxalate Monohydrate in Acid and Edta Solution

  • John Pawelchak
  • Douglas R. Flanagan
  • Anthony P. Simonelli

Abstract

In the past there has been varying degrees of clinical interest in dissolving renal calculi by some type of in situ irrigation technique. The physical-chemical rationale for the selection of the best irrigation solutions has been based on the equilibrium solubility of calcium oxalate or other stone minerals in the particular medium without regard to other possible factors which may govern the dissolution process.

Keywords

EDTA Oxalate Spectrophotometry Monohydrate 

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References

  1. 1.
    A. P. Simonelli, S. C. Mehta, and W. I. Higuchi, J. Pharm. Sci. 58:583 (1969).CrossRefGoogle Scholar
  2. 2.
    J. Pawelchak, D. R. Flanagan, and A. P. Simonelli, in: “Proceedings of the Fourth International Symposium on Urolithiasis Research,” L. H. Smith, B. Finlayson, W. G. Robertson, eds. Plenum Press, New York (in press).Google Scholar
  3. 3.
    J. Pawelchak, D. R. Flanagan, and A. P. Simonelli, in: “Proceedings of the Fourth International Symiposium on Urolithiasis Research,” L. H. Smith, B. Finlayson, W. G. Robertson, eds. Plenum Press, New York (in press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • John Pawelchak
    • 1
  • Douglas R. Flanagan
    • 1
  • Anthony P. Simonelli
    • 1
  1. 1.School of Pharmacy and Institute of Materials ScienceUniversity of ConnecticutStorrsUSA

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