Stabilizing Factors for Uric Acid Dihydrate — A Contribution to Uric Acid Stone Formation
Recently several authors, by investigations of the topographical phase distribution in uroliths, were able to demonstrate uric acid dihydrate (UAD) in the outer parts of uric acid concrements1 analogous to weddellite in calcium oxalate stones. Scanning electron microscopic studies by our team2,6 also suggest that initially dihydrate is formed, similar to a mechanism suggested for calcium oxalate stone genesis. In the opinion of other authors, one or several urine components can stabilize the metastable UAD phase within a certain pH range3,4. This was an essential starting point for the investigations under discussion.
KeywordsUric Acid Chondroitin Sulfate Scan Electron Microscopic Study Calcium Oxalate Stone High Uric Acid
Unable to display preview. Download preview PDF.
- 1.G. Brien, C. Bick, and G. Schubert, Jenaer Harnsteinsymposium, Wissenschaftliche Beitrage der Friedrich-Schiller-Universitat, Jena S.76 (1977).Google Scholar
- 2.W. Berg, A. Hesse, and H.-J. Schneider, Jenaer Harnsteinsymposium, Wissenschaftliche Beitrage der Friedrich-Schiller-Universitat, Jena S.101 (1977).Google Scholar
- 3.C. J. Laue, G. H. Nancollas, and S. J. Ko, Invest. Urol. 15:473 (1978).Google Scholar
- 5.J. G. Jediny, Allunionskongreß für Urologie, Kiew S.391 (1978).Google Scholar
- 6.A. Hesse, W. Berg, and C. Bothor, Int. Urol. Nephrology 11:13 (1979).Google Scholar