Urolithiasis pp 453-457 | Cite as

Calcium Oxalate Hydrates. Dissolution, Transformation and Crystallization Studies

  • Branko B. Tomazic
  • George H. Nancollas


Many calcium oxalate renal stones consist of an inner core of monohydrate (COM) with an outer surface layer of the thermodynamically less stable dihydrate (COD)1. The kinetic relationships between the hydrates may, therefore, be of considerable importance since these phases may form either directly or via a transformation process in the continuously changing urine environment. In vivo, the process of formation and dissolution of kidney stones is complicated by the presence of uncharacterized natural inhibitors and promoters which may markedly influence the nature of the hydrate phase which precipitates. Thus it has been shown that natural urine constituents selectively control the rate of nucleation and crystallization of the calcium oxalates2.


Kidney Stone Inner Core Renal Stone Calcium Oxalate Ionic Medium 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Branko B. Tomazic
    • 1
  • George H. Nancollas
    • 1
  1. 1.Chemistry DepartmentState University of New York at BuffaloBuffaloUSA

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