Urolithiasis pp 421-425 | Cite as

Calcium Electrode Measurements of Calcium Oxalate Mineralization: The Effects of Urine and other Inhibitors

  • W. P. Tew
  • C. D. Malis


In recent years, investigators in the field of nephrolithiasis have employed numerous in vitro assays to measure the kinetics of the formation and crystal growth of hydroxyapatite or calcium oxalate seed crystals in solutions supersaturated with respect to these salts 1, 2. Such assays have proven to be very accurate but their relevance to the formation and growth of urinary calculi is still uncertain. In this connection we have developed a procedure using a Ca2+- specific electrode which measures the rate and extent of calcium oxalate mineralization from initial ion-pair formation to the growth of calcium


Induction Period Induction Time Calcium Oxalate Seed Crystal Assay Medium 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • W. P. Tew
    • 1
  • C. D. Malis
    • 1
  1. 1.Department of Physiological ChemistryThe Johns Hopkins University, School of MedicineBaltimoreUSA

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