A Constant Composition Method for Modelling Urinary Stone Formation
Much attention has been paid recently to the development of an in vitro system for modelling the formation of renal stones. Although one of the major components of the renal stones is calcium oxalate, this may consist of the mono- (COM), di (COD), or tri- (COT) hydrate and the urine may be supersaturated with respect to any or all of these phases. Thus the less stable COD and COT may act as precursors to the formation of COM, precipitating and dissolving transiently. It is generally accepted that urine contains inhibitors to crystallization of calcium oxalates which may be absent in stone formers and studies have focused on the nature and mechanism of the mineralization inhibition of urine.
KeywordsRenal Stone Calcium Oxalate Calcium Oxalate Monohydrate Potassium Oxalate Oxalate Solution
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- 10.P. G. Koutsoukos, M. E. Sheehan, and G. H. Nancollas, Invest. Urol, (in press).Google Scholar