Urolithiasis pp 391-399 | Cite as

A Constant Composition Method for Modelling Urinary Stone Formation

  • Mary E. Sheehan
  • George H. Nancollas


Much attention has been paid recently to the development of an in vitro system for modelling the formation of renal stones. Although one of the major components of the renal stones is calcium oxalate, this may consist of the mono- (COM), di (COD), or tri- (COT) hydrate and the urine may be supersaturated with respect to any or all of these phases. Thus the less stable COD and COT may act as precursors to the formation of COM, precipitating and dissolving transiently. It is generally accepted that urine contains inhibitors to crystallization of calcium oxalates which may be absent in stone formers and studies have focused on the nature and mechanism of the mineralization inhibition of urine.


Renal Stone Calcium Oxalate Calcium Oxalate Monohydrate Potassium Oxalate Oxalate Solution 
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  1. 1.
    B. Finlayson, Invest. Urol. 9:258 (1972).PubMedGoogle Scholar
  2. 2.
    J. D Miller, A. D. Randolph, and G. W. Drach, J. Urol. 117:342 (1977).PubMedGoogle Scholar
  3. 3.
    G. H. Nancollas, and G. L. Gardner, J. Crystal Growth 21:267 (1974).CrossRefGoogle Scholar
  4. 4.
    J. L. Meyer, and L. H. Smith, Invest. Urol. 13:31 (1975).PubMedGoogle Scholar
  5. 5.
    J. L. Meyer, and L. H. Smith, Invest. Urol. 13:36 (1975).PubMedGoogle Scholar
  6. 6.
    M.E Sheehan, and G. H. Nancollas, Invest. Urol. 17:446 (1980).PubMedGoogle Scholar
  7. 7.
    W. Davies, and G. H. Nancollas, Trans. Faraday Soc. Land. 51:823 (1955).CrossRefGoogle Scholar
  8. 8.
    B.B Tomazic, and G. H. Nancollas, Invest. Urol. 16:329 (1979).PubMedGoogle Scholar
  9. 9.
    L.C Bell, A. M. Posner, and J. P. Quirk, J. Coll. Int. Sci. 42:250 (1973).CrossRefGoogle Scholar
  10. 10.
    P. G. Koutsoukos, M. E. Sheehan, and G. H. Nancollas, Invest. Urol, (in press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Mary E. Sheehan
    • 1
  • George H. Nancollas
    • 1
  1. 1.Chemistry DepartmentState University of New York at BuffaloBuffaloUSA

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