Reduction of Urinary Oxalate Excretion in Primary Hyperoxaluria by Diet
The medical management of primary hyperoxaluria poses a difficult therapeutic challenge1. The administration of pyridoxine, which facilitates the transamination of glyoxylate to glycine occasionally results in a worthwhile reduction of urine oxalate excretion2–4 but often is without significant effect2,5,6,7. Recently Smith has reported encouraging results with the combined use of pyridoxine and orthophosphates which prevented progression of nephrolithiasis and deterioration of renal function in this disease8.
KeywordsSodium Benzoate Oxalate Excretion Primary Hyperoxaluria Urinary Oxalate Excretion Oxalate Content
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- 1.H. E. Williams and L. H. Smith Jr., in: “The Metabolic Basis of Inherited Disease,” Fourth edition, J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds., McGraw-Hill Book Company, New York (1978).Google Scholar
- 8.L. H. Smith, in: “Fogarty International Center Proceedings 37,” R. Van Reen, ed., DREW Publication No. (NIH) 77–1063, Washington, D.C. (1977).Google Scholar