The Importance of Chronic Cadmium Poisoning in Renal Stone Formation — A Five Year Study
It is now recognized that although cadmium affects a wide variety of tissues the kidney is the organ most susceptible to damage by this nonessential toxic trace element. In early studies of chronic cadmium poisoning it was realized that the subjects had hypercalciuria and along with this an increased tendency to have renal stone disease1. Subsequent studies have confirmed that in addition to biochemical effects such as renal tubular acidosis, phosphaturia and amino aciduria indicating renal tubular damage2,3 hypercalciuria is a prominent feature of chronic cadmium poisoning4,5. Very few studies exist however which have followed the progress of stone formation and hypercalciuria in cadmium-exposed workers.
KeywordsStone Disease Renal Tubular Acidosis Serum Inorganic Phosphate Level Urine Cadmium Blood Cadmium
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