Urolithiasis pp 353-357 | Cite as

The Importance of Chronic Cadmium Poisoning in Renal Stone Formation — A Five Year Study

  • R. Scott
  • O. P. Fitzgerald-Finch
  • C. Cunningham
  • J. M. Ottoway
  • G. S. Fell


It is now recognized that although cadmium affects a wide variety of tissues the kidney is the organ most susceptible to damage by this nonessential toxic trace element. In early studies of chronic cadmium poisoning it was realized that the subjects had hypercalciuria and along with this an increased tendency to have renal stone disease1. Subsequent studies have confirmed that in addition to biochemical effects such as renal tubular acidosis, phosphaturia and amino aciduria indicating renal tubular damage2,3 hypercalciuria is a prominent feature of chronic cadmium poisoning4,5. Very few studies exist however which have followed the progress of stone formation and hypercalciuria in cadmium-exposed workers.


Stone Disease Renal Tubular Acidosis Serum Inorganic Phosphate Level Urine Cadmium Blood Cadmium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    L. Friberg, Acta. Med. Scand. (Suppl) 138:240 (1950).Google Scholar
  2. 2.
    K. S. Williamson, S. A. Roach, D. E. Hickish, M. F. Claydon, J. R. Glover, R. Owen, and D. Turner, Ann. Occup. Hyg. 20:215 (1977).CrossRefGoogle Scholar
  3. 3.
    R. R. Lauwerys, J. P. Buchet, H. A. Roels, J. Brouwers, and D. Stanescu, Arch. Environ. Health 28:145 (1974).PubMedGoogle Scholar
  4. 4.
    R. Scott, P. J. Paterson, R. Burns, J. M. Ottoway, F. E. R. Hussain, G. S. Fell, S. Dumbuya, and M. Iqbal, Urology 11:462 (1978).PubMedCrossRefGoogle Scholar
  5. 5.
    G. Kazantzis, in: “First International Conference on Cadmium,” San Francisco (1977).Google Scholar
  6. 6.
    R. Scott, P. J. Paterson, E. A. Mills, A. McKirdy, G. S. Fell, J. M. Ottoway, F. E. R. Hussain, O. P. Fitzgerald Finch, A. J. Yates, A. Lamont, and S. Roxburgh, Lancet 2:396 (1976).PubMedCrossRefGoogle Scholar
  7. 7.
    R. Scott, R. Freeland, W. Mowat, P. J. Paterson, P. S. Orr, A. J. Yates, and E. A. Mills, in: “Proceedings International Conference on Urolithiasis, Perth,” (1979) (in press).Google Scholar
  8. 8.
    H. Welinder, S. Skerfving, and O. Henriksen, Br. J. Industr. Med. 34:221 (1977).Google Scholar
  9. 9.
    J. Lener and J. Musil, Experientia 27:902 (1971).PubMedCrossRefGoogle Scholar
  10. 10.
    R. A. Coyer, K. Tsuchiya, D. L. Leonard, and H. Kahyo, Am. J. Clin. Pathol. 57:635 (1972).Google Scholar
  11. 11.
    M. G. Cherian, R. A. Coyer, and L. Delaquerrieve-Richardson, Appl. Pharmacol. 38:399 (1976).CrossRefGoogle Scholar
  12. 12.
    J. A. Bonnell, J. H. Ross, and E. King, Br. J. Indust. Hyg. 17:69 (1960).Google Scholar
  13. 13.
    E. Aughey and R. Scott, Munich (1977).Google Scholar
  14. 14.
    M. Ando, Y. Sayato, M. Tono-mura, and T. Osawa, Toxicol. Appl. Pharmacol. 39:321 (1977).PubMedCrossRefGoogle Scholar
  15. 15.
    R. Scott, J. K. Haywood, K. Boddy, E. D. Williams, I. Harvey, and P. J. Paterson, Urology 15:356 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • R. Scott
    • 1
  • O. P. Fitzgerald-Finch
    • 1
  • C. Cunningham
    • 1
  • J. M. Ottoway
    • 1
  • G. S. Fell
    • 1
  1. 1.Departments of Urology, Radiology and BiochemistryRoyal Infirmary, Glasgos, and University of StrathclydeGlasgowScotland

Personalised recommendations