Phosphate Treatment of Idiopathic Calcium Stone Disease
Thirty-nine patients with active idiopathic calcium stone disease were treated with 1g phosphorus/day given as “Phosphate Sandoz.” The urinary stone episode rate was calculated and blood and urine biochemistry measured before and on treatment.
Three patients increased their stone episode rate and four failed follow-up. In the remainder the stone episode rate was reduced from 0.74 to 0.24/patient year. There was a sustained and significant rise in 24-hour phosphate excretion and fall in calcium excretion. Urine volume, oxalate and pH were unchanged. The urine supersaturation with calcium phosphate increased and with calcium oxalate decreased. Calcium absorption was unchanged and there was no evidence of increased parathyroid hormone secretion.
Oral phosphorus treatment, 1g/day, is successful in reducing the stone recurrence rate in the majority of idiopathic calcium stone formers and does not give rise to serious side effects.
KeywordsCalcium Phosphate Calcium Oxalate Renal Tubular Acidosis Phosphate Treatment Parathyroid Hormone Secretion
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