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Urolithiasis pp 259-265 | Cite as

Phosphate Treatment of Idiopathic Calcium Stone Disease

  • M. Peacock
  • W. G. Robertson
  • P. J. Heyburn
  • A. E. J. Davies
  • A. Rutherford

Summary

  1. 1.

    Thirty-nine patients with active idiopathic calcium stone disease were treated with 1g phosphorus/day given as “Phosphate Sandoz.” The urinary stone episode rate was calculated and blood and urine biochemistry measured before and on treatment.

     
  2. 2.

    Three patients increased their stone episode rate and four failed follow-up. In the remainder the stone episode rate was reduced from 0.74 to 0.24/patient year. There was a sustained and significant rise in 24-hour phosphate excretion and fall in calcium excretion. Urine volume, oxalate and pH were unchanged. The urine supersaturation with calcium phosphate increased and with calcium oxalate decreased. Calcium absorption was unchanged and there was no evidence of increased parathyroid hormone secretion.

     
  3. 3.

    Oral phosphorus treatment, 1g/day, is successful in reducing the stone recurrence rate in the majority of idiopathic calcium stone formers and does not give rise to serious side effects.

     

Keywords

Calcium Phosphate Calcium Oxalate Renal Tubular Acidosis Phosphate Treatment Parathyroid Hormone Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W. G. Robertson, M. Peacock, R. W. Marshall, C. F. Varnavides, P. J. Heyburn, and B. E. C. Nordin, in: “Urolithiasis Research,” H. Fleisch, W. G. Robertson, L. H. Smith, and W. Vahlensieck, eds. Plenum Press, New York/London (1976).Google Scholar
  2. 2.
    L. H. Smith, W. C. Thomas, and C. D. Arnaud, in: “Urinary Calculi: Recent Advances in Aetiology, Stone Structure and Treatment,” L. Cifuentes Delatte, A. Rapado, and A. Hodgkinson, eds. Karger, Basel (1973).Google Scholar
  3. 3.
    B. Ettinger, and F. O. Kolb, Am. J. Med. 52:32 (1973).CrossRefGoogle Scholar
  4. 4.
    “Calcium, Phosphate and Magnesium Metabolism,” B. E. C. Nordin, ed., Churchill Livingstone, Edinburgh/London (1976).Google Scholar
  5. 5.
    K. Lau, C. Wolf, P. Nussbaum, B. Weiner, P. De Oreo, E. Slatopolsky, Z. Agus, and S. Goldfarb, Kid. Int. 16:736 (1979).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • M. Peacock
    • 1
  • W. G. Robertson
    • 1
  • P. J. Heyburn
    • 1
  • A. E. J. Davies
    • 1
  • A. Rutherford
    • 1
  1. 1.M.R.C. Mineral Metabolism UnitThe General InfirmaryLeedsUK

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