Infection-Induced Stones: Status of Clinic Trials with Urostat™ (Acetohydroxamic Acid)
The cause and effect relationship between urinary infection and urinary stones has been since antiquity. Bladder stones that we now perceive as infection induced have been found in Egyptian mummies dating back to 5,000 B.C. Hippocrates recognized that putrifying loin abscesses were commonly associated with renal stones. Marcet (1817) suggested that the evolution of ammonia during putrification alkalinized urine and that such alkalinization was “unavoidably attended by the precipitation of phosphates contained in urine.” Recent experimental and clinical investigations from a number of investigators have validated these historical concepts.
KeywordsHydroxamic Acid Urinary Stone White Blood Count Ileal Conduit Bladder Stone
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