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Urolithiasis pp 199-208 | Cite as

Infection-Induced Stones: Status of Clinic Trials with Urostat™ (Acetohydroxamic Acid)

  • Donald P. Griffith
  • Pat Moskowitz
  • Stuart Feldman

Abstract

The cause and effect relationship between urinary infection and urinary stones has been since antiquity. Bladder stones that we now perceive as infection induced have been found in Egyptian mummies dating back to 5,000 B.C. Hippocrates recognized that putrifying loin abscesses were commonly associated with renal stones. Marcet (1817) suggested that the evolution of ammonia during putrification alkalinized urine and that such alkalinization was “unavoidably attended by the precipitation of phosphates contained in urine.” Recent experimental and clinical investigations from a number of investigators have validated these historical concepts.

Keywords

Hydroxamic Acid Urinary Stone White Blood Count Ileal Conduit Bladder Stone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    D. P. Griffith, R. R. Bruce, and W. N. Fishbein, in: “Nephrolithiasis,” F. L. Coe, B. M. Brenner, and J. H. Stein, eds., Churchill Livingstone, New York, p. 231 (1980).Google Scholar
  2. 2.
    C. Sato, Personal communication.Google Scholar
  3. 3.
    J. Donnelly, R. H. Hackler, and R. C. Brents, J. Urol. 108: 558 (1972).PubMedGoogle Scholar
  4. 4.
    D. P. Griffith, Kid. Int. 13:372 (1978).CrossRefGoogle Scholar
  5. 5.
    R. Bruce and D. P. Griffith, in: “Proceedings of the IV International Symposium on Urolithiasis Research,” (in press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Donald P. Griffith
    • 1
  • Pat Moskowitz
    • 1
  • Stuart Feldman
    • 1
  1. 1.Department of UrologyBaylor College of MedicineHoustonUSA

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