Urolithiasis pp 179-190 | Cite as

Therapy for Enteric Hyperoxaluria: A Comparison of Calcium Supplementation and Urinary Alkalinization

  • John G. Gregory
  • Ki Y. Park
  • Robert Wilt
  • Alex Feigl


Of the commonly considered factors causatively related to calcium oxalate stone formation; urinary pH, inhibitor factors, urinary volume, levels of calcium, oxalate, and uric acid, it appears at the present time that the level of urinary oxalate is the factor most significantly responsible for stone formation1. Such being the case, it is intuitively reasonable to consider with particular interest any patients having a predisposition toward the hyperoxaluric state. No large group of patients is better suited for such a study than are those who have enteric hyperoxaluria. Since 1972 we have had occasion to study 681 patients who have had a small bowel bypass procedure performed for reasons of morbid obesity.


Stone Formation Urinary Calcium Calcium Oxalate Oxalate Calcium Urinary Oxalate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    W. G. Robertson, M. Peacock, P. J. Heyburn, A. H. Marshall, and P. B. Clark, Br. J. Urol. 50:449 (1978).PubMedCrossRefGoogle Scholar
  2. 2.
    J. G. Gregory, K. Y. Park, and H. W. Schoenberg, J. Urol. 117:631 (1977).PubMedGoogle Scholar
  3. 3.
    A. Hodgkinson, Clin. Sci. Mol. Med. 54:291 (1978).PubMedGoogle Scholar
  4. 4.
    V. S. Chadwick, K. Modha, and R. H. Dowling, N. Eng. J. Med. 289:172 (1973).CrossRefGoogle Scholar
  5. 5.
    D. L. Earnest, G. Johnson, H. E. Williams, and W. H. Admerand, Gastroenterology 66:1114 (1974).PubMedGoogle Scholar
  6. 6.
    R. Modigliani, D. Labayle, C. Aymes, and R. Denvil, Scand. J. Gastroenterology 13:2 (1978).CrossRefGoogle Scholar
  7. 7.
    D. L. Earnest, Trans. Assoc. Am. Phys. 88:224 (1975).PubMedGoogle Scholar
  8. 8.
    I. Hessov, C. N. Holm, and L. P. Hansen, Digestion 17:268 (1978)PubMedCrossRefGoogle Scholar
  9. 9.
    K. Y. Park and J. G. Gregory, Clin. Chem. 26:1170 (1980).PubMedGoogle Scholar
  10. 10.
    C. Y. C. Pak and M. Ohata, Kid. Int. 7:154 (1975).CrossRefGoogle Scholar
  11. 11.
    C. Y. C. Pak, Y. Hayashi, B. Finlayson, and S. Chu, J. Lab. Clin. Med. 89:891 (1977).PubMedGoogle Scholar
  12. 12.
    C. Y. C. Pak and S. Chu, Invest. Urol. 11:211 (1973)PubMedGoogle Scholar
  13. 13.
    J.Q. Stauffer, Am. J. Clin. Nutr. 30:64 (1977).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • John G. Gregory
    • 1
  • Ki Y. Park
    • 1
  • Robert Wilt
    • 1
  • Alex Feigl
    • 1
  1. 1.Section of UrologySt. Louis University School of MedicineSt. LouisUSA

Personalised recommendations