Urolithiasis pp 169-172 | Cite as

Prevalence of Nephrolithiasis in Malabsorptive Syndromes

  • K. Dharmsathaphorn
  • D. Freeman
  • H. J. Binder
  • J. Dobbins


Patients with inflammatory bowel disease have an increased incidence of nephrolithiasis, especially after resection or bypass of part of the bowel1. Many of these stones are composed of calcium oxalate though uric acid stones appear to be more common after an ileostomy. Patients with ileal disease have increased absorption of dietary oxalate, with resultant hyperoxaluria, because of increased solubility of oxalate and increased permeability of the colon to oxalate1. Increased solubility is related to steatorrhea. Unabsorbed fatty acids bind to calcium preventing the formation of insoluble calcium oxalate, thus oxalate remains in solution available for absorption. Fatty acids (and bile acids) also increase the permeability of the colon to oxalate2.


Uric Acid Celiac Disease Primary Biliary Cirrhosis Serum Uric Acid Kidney Stone 
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  1. 1.
    J. W. Dobbins, J. Clin. Gastroenterol. 1:165 (1979)PubMedCrossRefGoogle Scholar
  2. 2.
    J. W. Dobbins and H. J. Binder, Gastroenterology 70:1096 (1976).PubMedGoogle Scholar
  3. 3.
    E. Hylander, S. Jarnum, K. J. Jensen, and M. Thale, Scand. J. Gastroenterol. 13:577 (1978).PubMedCrossRefGoogle Scholar
  4. 4.
    G. B. McDonald, D. L. Earnest, and W. H. Admirand, Gut 18:561 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    H. Andersson and R. Gillberg, Lancet 2:677 (1977).PubMedCrossRefGoogle Scholar
  6. 6.
    H. J. Binder, Gastroenterology 65:847 (1973).PubMedGoogle Scholar
  7. 7.
    W. G. Cochran, in: “Statistical Methods,” 6th edition. State University Press, Ames, Iowa (1967).Google Scholar
  8. 8.
    Y. M. M. Bishop, S. E. Fienberg, and P. W. Holland, in: “Discrete Multivariate Analysis,” MIT Press, Cambridge, Massachusetts (1975).Google Scholar
  9. 9.
    J. J. Deren, J. G. Porush, M. F. Levit, and M. G. Khilnani, Ann. Int. Med. 56:843 (1962).PubMedGoogle Scholar
  10. 10.
    E. A. Gelzayd, R. I. Breuer, and J. B. Kirsner, Am. J. Dig. Dis. 13:1027 (1968).PubMedCrossRefGoogle Scholar
  11. 11.
    L. H. Smith, P. G. Werness, D. M. Wilson, and S. F. Phillips, (abstract) Clin. Res. 28:486A (1980).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • K. Dharmsathaphorn
    • 1
  • D. Freeman
    • 1
  • H. J. Binder
    • 1
  • J. Dobbins
    • 1
  1. 1.Department of Internal MedicineYale University School of MedicineNew HavenUSA

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