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Urolithiasis pp 169-172 | Cite as

Prevalence of Nephrolithiasis in Malabsorptive Syndromes

  • K. Dharmsathaphorn
  • D. Freeman
  • H. J. Binder
  • J. Dobbins

Abstract

Patients with inflammatory bowel disease have an increased incidence of nephrolithiasis, especially after resection or bypass of part of the bowel1. Many of these stones are composed of calcium oxalate though uric acid stones appear to be more common after an ileostomy. Patients with ileal disease have increased absorption of dietary oxalate, with resultant hyperoxaluria, because of increased solubility of oxalate and increased permeability of the colon to oxalate1. Increased solubility is related to steatorrhea. Unabsorbed fatty acids bind to calcium preventing the formation of insoluble calcium oxalate, thus oxalate remains in solution available for absorption. Fatty acids (and bile acids) also increase the permeability of the colon to oxalate2.

Keywords

Uric Acid Celiac Disease Primary Biliary Cirrhosis Serum Uric Acid Kidney Stone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • K. Dharmsathaphorn
    • 1
  • D. Freeman
    • 1
  • H. J. Binder
    • 1
  • J. Dobbins
    • 1
  1. 1.Department of Internal MedicineYale University School of MedicineNew HavenUSA

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