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Urolithiasis pp 125-130 | Cite as

2, 8-Dihydroxyadeninuria: Or When is a Uric Acid Stone not a Uric Acid Stone?

  • H. A. Simmonds
  • K. J. Van Acker
  • M. J. Dillon
  • T. M. Barratt
  • C. F. Potter
  • A. Sahota
  • J. S. Cameron

Abstract

Purine nucleotides important for normal cellular metabolism are derived endogenously from de novo synthesis and also from recycling of pre-formed purines via the so-called salvage pathway (Figure 1). The latter pathway contains a number of enzymes, the absence of which can lead to disturbances of purine metabolism and also severe clinical symptoms1. An example is the deficiency of the salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT) which can lead either to the Lesch-Nyhan syndrome or X-linked gout1.

Keywords

Uric Acid Xanthine Oxidase Purine Metabolism Uric Acid Stone Normal Cellular Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • H. A. Simmonds
    • 1
  • K. J. Van Acker
    • 2
  • M. J. Dillon
    • 3
  • T. M. Barratt
    • 3
  • C. F. Potter
    • 1
  • A. Sahota
    • 1
  • J. S. Cameron
    • 1
  1. 1.Purine LaboratoryGuy’s Hospital Medical SchoolLondon BridgeUK
  2. 2.Department of PediatricsUniversity of AntwerpWilrijkBelgium
  3. 3.The Hospital for Sick ChildrenLondonUK

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