Renal Stone Formation in Primary Hyperparathyroidism — Role of Tubular Dysfunction
The formation of calcium stones is perhaps the best recognized feature of primary hyperparathyroidism (HPT). Its frequency in different clinical series varies from 25% – 50%, the lowest figure being obtained in the most recent studies, where HPT was detected fortuitously during health screening studies. The mechanism for the markedly increased propensity for stones in HPT are not entirely clarified. For obvious reasons most interest has been directed to investigations of calcium metabolism but although HPT patients with stones have a higher mean urinary calcium than the stone-free individuals1, hypercalciuria alone can not explain why some, but not all, HPT patients form stones.
KeywordsPrimary Hyperparathyroidism Urinary Calcium Renal Tubular Acidosis Tubular Dysfunction Distal Renal Tubular Acidosis
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- 2.F. P. Muldowney, D. V. Carroll, J. F. Donohoe, and R. Freany, Quart. J. Med. 160:487 (1971).Google Scholar