Urolithiasis pp 969-976 | Cite as

Direct Measurement of Ionized Calcium (Standardization, Normal Values and Clinical Results)

  • B. M. Ulshöfer
  • A. Peemöller


Ionized calcium (Ca++) is the biologically active fraction of total serum calcium (Cat), thus it is of special clinical interest. In the diagnosis of primary hyperparathyroidism (pHPT) none of the previously reported methods1–5 for measuring (Ca)++ have become clinically useful because of cost. The development of a (Ca)++- selective membrane6 provided a simpler and more specific measurement of (Ca)++. The Orion SS-20 (R) made this technique available for clinical purposes. In order to evaluate this procedure we determined the factors that influence ionization7–10 and studied the usefulness11–14 of the procedure in the diagnosis of pHPT.


Primary Hyperparathyroidism Venous Stasis Selective Membrane6 pHPT Patient Careful Maintenance 


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  1. 1.
    F. C. McLean and A. B. Hastings, Am. J. Med. Sci. 189:601 (1935).CrossRefGoogle Scholar
  2. 2.
    E. R. Yendt, T. B. Connor, and J. E. Howard, Bull. Johns Hopkins Hosp. 96:1 (1955).PubMedGoogle Scholar
  3. 3.
    W. G. Robertson, Clin. Chim. Acta. 20:315 (1968).PubMedCrossRefGoogle Scholar
  4. 4.
    J. Raaflaub, Z. Physiol. Chem. 288:228 (1951).Google Scholar
  5. 5.
    G. A. Rose, Clin. Chim. Acta. 2:227 (1957).PubMedCrossRefGoogle Scholar
  6. 6.
    J. W. Ross, Science 156:1378 (1967).PubMedCrossRefGoogle Scholar
  7. 7.
    Instruction Manual Space-Stat 20 Ionized Calcium Analyzer. Orion Biomedical, Division of Orion Research Inc., Cambridge, Massachusetts (1976).Google Scholar
  8. 8.
    H. Husdan, M. Lenug, D. Oreopoulos, A. Rappaport, Clin. Chem. 23:1775 (1977).PubMedGoogle Scholar
  9. 9.
    K. Paschen, in: “Die Bestimmung des Calciums und Seiner Fraktionen im Serum,” Thieme-Verlag, Stuttgart, West Germany (1975).Google Scholar
  10. 10.
    C. Fuchs, D. Dorn, C. Mcintosh, and F. Scheler, Clin. Chim. Acta. 67:99 (1976).PubMedCrossRefGoogle Scholar
  11. 11.
    J. C. Low, M. Schaaf, J. M. Earll, J. T. Plechoki, and T. K. Li, JAMA 152:223 (1973).Google Scholar
  12. 12.
    F. P. Muldowney, R. Freaney, E. A. Spillane, and P. O’Donohoe, Irish J. Med. Sci.142:223 (1973).PubMedCrossRefGoogle Scholar
  13. 13.
    B. Ulshofer and G. Rodeck, Akt. Urol. 9:43 (1978).Google Scholar
  14. 14.
    B. Ulshofer, K. Joseph and G. Rodeck, Helv. Chir. Acta. 46:399 (1979).PubMedGoogle Scholar
  15. 15.
    W. Moore, in: “National Bureau of Standards,” R. Durst, ed., Gaithersburg, Maryland (1969).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • B. M. Ulshöfer
    • 1
  • A. Peemöller
    • 1
  1. 1.Urologische Universitätsklinik und PoliklinikMarburg a.d. LahnGermany

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