Urate metabolism has been extensively investigated in calcium stone disease. Some investigators have reported that hyperuricemia was a common feature among stone formers1; whereas this could not be reproduced by others2. Increasing attention has been focused on the amount of urate in urine in calcium stone formers. Hyperuricosuria has been reported3 to be more frequent among stone formers than healthy controls and suggested to reflect overconsumption of dietary purines as animal protein4,5.Two mechanisms have been proposed to explain the connection between urinary urate and calcium oxalate stone formation. One is the possibility of epitaxial growth of calcium oxalate on uric acid or sodium urate crystals6. The other is that urate should act as an anti-inhibitor through complex binding of naturally occurring acid mucopolysaccarides in the urine7. The purpose of the present study was to evaluate to what extent disturbances in urate metabolism were present among our stone formers and characterize their clinical picture.
KeywordsCalcium Oxalate Serum Urate Calcium Stone Stone Operation Stone Episode
Unable to display preview. Download preview PDF.
- 7.W. G. Robertson, in: “Urolithiasis Research,” H. Fleisch, W. G. Robertson, L. H. Smith, and W. Vahlensieck, eds,. Plenum Press (1976).Google Scholar