Urinary Excretion of Amino Acids by Subjects with Renal Calculi
Idiopathic calcareous calculi remains a disorder of unknown cause, or causes. However, this affliction occurs predominantly in nonblack men, is affected by undefined geographic or climatic factors, and may be influenced by dietary habits1. In addition, the familial occurrence of idiopathic calculi has suggested that hereditary factors may exist that increase susceptability to this disorder2. Searching for a possible index of renal tubular dysfunction, McGeown3 investigated the amino acid excretion of 110 patients with calcareous calculi. She reported that, except for 30 patients with some increase in urinary cystine, the amino acid excretion was reduced in the calculous patients as compared with the amino acid excretion of normal subjects. Of these 110 patients, twenty-three had hyperparathyroidism and the mean excretion of amino acid nitrogen was less in these than in the group as a whole. Subsequently, Hum and associates4 reported the urinary amino acid values of 15 patients with calcareous calculi, but they found a reduced excretion only in those patients with impaired renal function.
KeywordsRenal Calculus Renal Tubular Dysfunction Amino Acid Nitrogen Medullary Sponge Kidney Urinary Amino Acid
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