Alterations in Kidney Enzymes of Oxalate Metabolism in Patients with Urolithiasis
McCarrison1 described northern India as a “stone-belt”, in which the stones are of a mixture of calcium oxalate and calcium phosphate2. Many etiological factors have been implicated in the formation of idiopathic renal calculi. Recent work on experimental urolithiasis in rats has shown that enzymes of oxalate metabolism are altered in stone formers3. In the present study the role of enzymes involved in urolithiasis in humans has been ascertained by measuring the activities of alkaline phosphatase (AP), lactate dehydrogenase (LDH), glycolate oxidase and glyoxylase I, from biopsy specimens of kidneys collected during operation.
KeywordsAlkaline Phosphatase Lactate Dehydrogenase Stone Formers3 Calcium Oxalate Human Kidney
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- 2.S. K. Thind and R. Nath, Ind. J. Med. Res. 57:1790 (1979).Google Scholar
- 3.S. K. Thind and R. Nath, Ind. J. Expt. Biol. 16:66 (1978).Google Scholar
- 4.E. Racker, J. Biol. Chem. 190:685 (1955).Google Scholar
- 5.G. H. Dixon and H. L. Romberg, in: “Methods in Enzymology,” S. P. Colowick and N. O. Kaplan, eds., Academic Press Inc., New York (1966).Google Scholar
- 8.I. D. P. Wooton, in: “Microanalysis in Medical Biochemistry,” J. & A. Churchill Ltd., London (1964).Google Scholar