Disturbed Terminal Mineralization of Bone in Idiopathic Hypercalciuria
Hypercalciuric renal stone-formers are commonly divided into 3 different groups: Resorptive hypercalciuria, hyperabsorptive and renal hypercalciuria1–4. Patients with hyperabsorptive hypercalciuria have normal or low serum parathyroid hormone activities and normal to low urinary excretion of cAMP. In renal hypercalciuria elevated serum PTH levels and increased renal excretion of cAMP has been reported4–6. Bordier et al.6 published elevated immunoreactive parathyroid hormone levels and increased numbers of osteoclasts in bone biopsies obtained from patients with renal hypercalciuria. No information is available on bone histology in patients with hypercalciuria of the hyperabsorptive type. The present study evaluates quantitatively bone sections in 15 patients with hyperabsorptive hypercalciuria and recurrent stone-formation.
KeywordsBone Biopsy Serum Phosphate Renal Tubular Acidosis Idiopathic Hypercalciuria Bone Histology
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