How to Prevent the Hyperresorption of Dietary Oxalate and the Oxalate Peaks in Urine
Our detailed investigations concerning the kinetics of Caoxalate and Ca-phosphate crystal growth from metastable and unstable solutions showed clearly that differences in oxalate concentration as small as 0.05–0.15 mM resulted in a distinct shift of the size- distribution curve of formed crystals toward bigger crystals and crystal aggregates. In the case of Ca2+ ions, the comparable increase in the average size of formed crystals can be achieved by changes in the Ca2+ concentration as high as 1.0–3.0 mM, this corresponds to a factor of 15–20. The effect of minimal changes in the oxalate concentration is enhanced furthermore if the oxalate load is prolonged. In urine, the stoichiometrically unfavorable molar Oxalate/calcium ratio of 1/20–1/30 could be responsible for the highly sensitive response of crystal growth to the minimal changes in the oxalate concentration.
KeywordsCalcium Sulfate Calcium Oxalate Urinary Oxalate Basic Anionic Exchanger Acidic Cationic Exchanger
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