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Urolithiasis pp 763-766 | Cite as

Influence of Changes in Calcium Metabolism on Renal Handling of Oxalate in Rats

  • H. Osswald
  • J. A. Haas
  • R. M. Meyer-Hentschel
  • R. Hautmann

Abstract

Clearance and micropuncture studies on the renal handling of oxalate in rats have led to conflicting results. There is wide agreement that oxalate is excreted into the urine 1.1 to 1.4 fold in excess of the filtered load1–4. In micropuncture studies in Sprague-Dawley rats, Weinman et al1 found not addition of oxalate to the filtered amount in the proximal tubule. However, Hautmann and Osswald 2 did not find oxalate secretion in the superficial proximal tubule of rats. In another study by Greger et al3, proximal tubular secretion of oxalate was found in Wistar rats. Since different experimental protocols (infused amount of saline and 14C oxalate) and different rat strains were used in the above cited studies, it was the aim of the present investigation to identify factors that can influence the renal handling of oxalate. In addition, the importance of calcium in controlling oxalate fluxes across the tubular epithelium was studied, to test the hypothesis that calcium in the tubular fluid might trap the oxalate ion.

Keywords

Proximal Tubule Sodium Citrate Oxalate Excretion Renal Handling Micropuncture Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    E. J. Weinman, S. J. Frankfurt, A. Ince, and S. Sansom, J. Clin. Invest. 61:801 (1978).Google Scholar
  2. 2.
    R. Hautmann, and H. Osswald, Naunyn-Schmiedebergs Arch. Pharm acol. 304:277 (1978).Google Scholar
  3. 3.
    R. Greger, F. Lang, H. Oberleithner, P. Deetjen, Pfluegers Arch. 374:243 (1978).Google Scholar
  4. 4.
    T. F. Knight, H. 0. Senekjian, and E. J. Weinman, Kid. Int. 15:38 (1979).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • H. Osswald
    • 1
    • 2
  • J. A. Haas
    • 1
    • 2
  • R. M. Meyer-Hentschel
    • 1
    • 2
  • R. Hautmann
    • 1
    • 2
  1. 1.Department of PharmacologyRWTHAachenWest Germany
  2. 2.Department of PhysiologyMayo ClinicRochesterUSA

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