Intracellular Mechanisms Underlying the Phosphaturic Response to Parathyroid Hormone in the Hamster
We previously reported the lack of a significant phosphaturic effect of parathyroid hormone (PTH) in the fasted hamster1. This response was in marked contrast to the fed hamster which is normally responsive to the phosphaturic effect of PTH2–4. The refractoriness to the phosphaturic effect of PTH in the fasted hamster was abolished by ammonium chloride infusions1,3. Additional studies showed that the ammonium ion itself, rather than the acute acidemia, is responsible for the restoration of the phosphaturic response to PTH5. In the present studies we evaluated the role of fasting induced changes in renal ammoniagenesis and metabolism in the resistance to the phosphaturic effect of PTH.
KeywordsFractional Excretion Clearance Study NADH Ratio NADH Level Phosphate Depletion
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