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Intracellular Mechanisms Underlying the Phosphaturic Response to Parathyroid Hormone in the Hamster

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Urolithiasis

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Abstract

We previously reported the lack of a significant phosphaturic effect of parathyroid hormone (PTH) in the fasted hamster1. This response was in marked contrast to the fed hamster which is normally responsive to the phosphaturic effect of PTH2–4. The refractoriness to the phosphaturic effect of PTH in the fasted hamster was abolished by ammonium chloride infusions1,3. Additional studies showed that the ammonium ion itself, rather than the acute acidemia, is responsible for the restoration of the phosphaturic response to PTH5. In the present studies we evaluated the role of fasting induced changes in renal ammoniagenesis and metabolism in the resistance to the phosphaturic effect of PTH.

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Author information

Authors and Affiliations

  1. Department of Physiology and Biophysics, Mayo Clinic and Foundation, 55901, Rochester, MN, USA

    Theresa Berndt, Stanislaw Czekalski, Marcine Onsgard, Anek Hoppe & Franklyn G. Knox

Authors
  1. Theresa Berndt
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  2. Stanislaw Czekalski
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  3. Marcine Onsgard
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  4. Anek Hoppe
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  5. Franklyn G. Knox
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Editor information

Editors and Affiliations

  1. Mayo Clinic, Rochester, Minnesota, USA

    Lynwood H. Smith

  2. The General Infirmary, Leeds, England

    William G. Robertson

  3. University of Florida, Gainesville, Florida, USA

    Birdwell Finlayson

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© 1981 Springer Science+Business Media New York

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Berndt, T., Czekalski, S., Onsgard, M., Hoppe, A., Knox, F.G. (1981). Intracellular Mechanisms Underlying the Phosphaturic Response to Parathyroid Hormone in the Hamster. In: Smith, L.H., Robertson, W.G., Finlayson, B. (eds) Urolithiasis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8977-4_118

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  • DOI: https://doi.org/10.1007/978-1-4684-8977-4_118

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8979-8

  • Online ISBN: 978-1-4684-8977-4

  • eBook Packages: Springer Book Archive

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