Urolithiasis pp 735-740 | Cite as

Intracellular Mechanisms Underlying the Phosphaturic Response to Parathyroid Hormone in the Hamster

  • Theresa Berndt
  • Stanislaw Czekalski
  • Marcine Onsgard
  • Anek Hoppe
  • Franklyn G. Knox


We previously reported the lack of a significant phosphaturic effect of parathyroid hormone (PTH) in the fasted hamster1. This response was in marked contrast to the fed hamster which is normally responsive to the phosphaturic effect of PTH2–4. The refractoriness to the phosphaturic effect of PTH in the fasted hamster was abolished by ammonium chloride infusions1,3. Additional studies showed that the ammonium ion itself, rather than the acute acidemia, is responsible for the restoration of the phosphaturic response to PTH5. In the present studies we evaluated the role of fasting induced changes in renal ammoniagenesis and metabolism in the resistance to the phosphaturic effect of PTH.


Fractional Excretion Clearance Study NADH Ratio NADH Level Phosphate Depletion 
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  1. 1.
    F. G. Knox, J. Preiss, J. K. Kim, and T. P. Dousa, J. Clin. Invest. 59:675 (1977).PubMedCrossRefGoogle Scholar
  2. 2.
    M. A. Burnatowska, C. A. Harris, R. A. L. Sutton, and J. H. Dirks, Am. J. Physiol. 233:F514 (1977).PubMedGoogle Scholar
  3. 3.
    C. A. Harris and J. F. Seely, Am. J. Physiol. 237:F175 (1979).PubMedGoogle Scholar
  4. 4.
    C. A. Harris, M. A. Burnatowska, J. F. Seely, R. A. L. Sutton, G. A. Quamme, and J. H. Dirks, Am. J. Physiol. 236:F342 (1979).PubMedGoogle Scholar
  5. 5.
    A. Hoppe, F. M. Destro, and F. G. Knox, Am. J. Physiol. (in press — 1980).Google Scholar
  6. 6.
    R. L. Blake and E. Kun, Methods Enzymol. 18:113 (1971).CrossRefGoogle Scholar
  7. 7.
    N. O. Kaplan, A. Goldin, S. R. Humphreys, M. M. Ciotti, and F. E. Stolzenbach, J. Biol. Chem. 219:287 (1956).PubMedGoogle Scholar
  8. 8.
    H. G. Preuss, J. Lab. Clin. Med. 72:370 (1968).PubMedGoogle Scholar
  9. 9.
    O. Siggaard-Andersen, Ann. N. Y. Acad. of Sei. 133:41 (1966).CrossRefGoogle Scholar
  10. 10.
    H. Klingenberg, in: “Methods of Enzyme Analysis,” H. U. Bergmeyer, ed., Academic Press, New York, 2nd Edition, 4:2045 (1974).CrossRefGoogle Scholar
  11. 11.
    A. Hoppe, J. L. Ziegler, and F. G. Knox, The Physiologist 21:56 (1978).Google Scholar
  12. 12.
    T. H. Steele, J. A. Underwood, B. A. Stromberg, and C. A. Larmore, J. Clin. Invest. 58:1461 (1976).PubMedCrossRefGoogle Scholar
  13. 13.
    N. Beck, Clin. Res. 27:408A (1979).Google Scholar
  14. 14.
    K. T. Borer, N. Rowland, A. Mirow, R. C. Borer, and R. P. Kelch, Am. J. Physiol. 236:E103 (1979).Google Scholar
  15. 15.
    G. Lemieux, P. Viney, P. Robitaille, G. E. Plante, Y. Lussier, and P. Martin, J. Clin. Invest. 50:1781 (1971).PubMedCrossRefGoogle Scholar
  16. 16.
    D. M. Röxe, G. E. Schreiner, and H. G. Preuss, Am. J. Physiol. 225:908 (1979).Google Scholar
  17. 17.
    G. Lemieux, G. Baverel, P. Viney, and A. Gougoux, Am. J. Physiol. 237:F7 (1979).PubMedGoogle Scholar
  18. 18.
    T. P. Dousa, S. A. Kempson, and L. Y. Qu, Am. Soc. for Pharmacol, and Exp. Ther. August, 1980 (abstract).Google Scholar
  19. 19.
    T. J. Berndt, F. G. Knox, S. A. Kempson, and T. P. Dousa, Am. Soc. for Pharmacol, and Exp. Ther. August, 1980 (abstract).Google Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Theresa Berndt
    • 1
  • Stanislaw Czekalski
    • 1
  • Marcine Onsgard
    • 1
  • Anek Hoppe
    • 1
  • Franklyn G. Knox
    • 1
  1. 1.Department of Physiology and BiophysicsMayo Clinic and FoundationRochesterUSA

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