Low Phosphate Diet in Rats: A Model for Calcium Oxalate Urolithiasis
Rats fed low phosphate diet show a marked hypercalciuria. We have shown previously that one week of low phosphate diet in rats results in urine highly supersaturated with respect to calcium oxalate with large amounts of calcium oxalate crystalluria, predominantly calcium oxalate dihydrate1. We have extended these studies to ten months and examined kidney tissue to evaluate the suitability of rats fed low phosphate diet as a long-term model for calcium oxalate urolithiasis.
KeywordsOxalic Acid Base Diet Stone Formation Calcium Oxalate Respective Diet
Unable to display preview. Download preview PDF.
- 1.P. G. Werness, P. H. Lee, T. J. Berndt, F. G. Knox, and L. H. Smith, Clin. Res. 27:710A (1979).Google Scholar
- 2.C. J. Van Den Berg, T. M. Cahill, and L. H. Smith, in: “Urolithiasis Research,” H. Fleisch, W. G. Robertson, L. H. Smith, and W. Vahlensieck, eds., Plenum Press, New York (1976).Google Scholar