On the Mechanism of Action of 1,25(OH)2D3 in the Intestine
One of the major effects of 1, 25 dihydroxyvitamin D3 on the small intestine is that of increasing the transcellular transport of calcium across the mucosal cells1, 2. Physiological data indicate that a major cellular site of action of this hormone is at the luminal or brush border membrane where it increases the rate of entry of calcium into the cell3. In an effort to gain an insight into the biochemical and molecular basis of this specific cellular effect of 1,25(OH)2D3, we have developed a method for preparing small osmotically-intact membrane vesicles from the brush border membranes of chick duodenal mucosal cells4.
KeywordsCalcium Uptake Brush Border Membrane Calcium Transport Transcellular Transport Intestinal Mucosal Cell
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