Nephrolithiasis in Dialysed Patients — Evidence for a Peculiar Type of Matrix Stones with Ca-Oxalate Inclusions
Recently it has been recognized by Bommer1 and Caralps2 that nephrolithiasis may arise de novo in patients on maintenance hemodialysis. Such stones were shown to consist of a protein matrix with amyloid-like microfibrillar ultrastructure. The organic phase consisted primarily of protein with little carbohydrate or lipid. A small admixture of inorganic material (whewellite) or ammonium-hydrogen-urate was found; the amount of which varied from 15–50% of dry weight in the study of Bommer1. The present study was designed (1) to further characterize the natural history of this type of nephrolithiasis, and (2) to further analyse the composition of the stones.
KeywordsMaintenance Hemodialysis Urinary Uric Acid Cast Formation Dilate Tubule Matrix Stone
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