The Role of Calcium in the Lethal Hit of T Lymphocyte-Mediated Cytolysis

  • Eric Martz
  • Wendy L. Parker
  • Maurice K. Gately
  • Constantine D. Tsoukas
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


The cytolytic T lymphocyte (CTL)1 inflicts lethal damage within minutes after contact with a specific antigen-bearing target cell. The mechanism of this damage remains a mystery. Elsewhere in this volume (1), we have reviewed progress during the past decade towards understanding the mechanism of CTL-mediated killing.


Mast Cell Histamine Release Calcium Influx Adhesion Formation Calcium Ionophore A23187 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Eric Martz
    • 1
  • Wendy L. Parker
    • 2
  • Maurice K. Gately
    • 3
  • Constantine D. Tsoukas
    • 4
  1. 1.Department of MicrobiologyUniversity of MassachusettsAmherstUSA
  2. 2.Department of MicrobiologyUniversity of Massachusetts Medical CenterWorcesterUSA
  3. 3.Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA
  4. 4.Department of Clinical ResearchScripps Clinic and Research FoundationLa JollaUSA

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