Effects of Concanavalin a Pretreatment on Cloned Cytolytic T Cells

  • Katherine A. Wall
  • Frank W. Fitch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


Concanavalin A (Con A) and some other lectins have been shown to facilitate lysis of antigenically irrelevant target cells by otherwise specific cytolytic T cells (CTL). The mechanism of the nonspecific recognition in such lectin-facilitated cytolysis is not yet understood; however, simple bridging is apparently not sufficient since some lectins may agglutinate cells and yet not cause target cell lysis (1).


Target Cell Effector Cell Lytic Activity Spontaneous Release Peritoneal Exudate Cell 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Katherine A. Wall
    • 1
  • Frank W. Fitch
    • 1
  1. 1.Department of PathologyUniversity of ChicagoChicagoUSA

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