Inhibition of Human T Cell Mediated Cytolysis by Monoclonal Antibodies to Effector Cell Surface Structures
Monoclonal antibody (mAb) technology has recently permitted the delineation of human functional T cell compartments involved in the generation of T and B cell responses (for review see 1,2,3). Most of these mAb were initially selected for their differential staining of lymphoid or T cell subpopulations. This approach relies on the assumption that the cellular distribution of some cell surface antigens matches the occurrence of given immunological functions. Nevertheless, when introduced in the absence of complement in functional assays such as T cell mediated cytolysis or specific proliferation to soluble or cellular antigens, only a small percentage of these functional subset-discriminating mAb was shown to modulate immunological functions and thus to define “Lymphocyte functionassociated antigens” (4).
KeywordsImmunological Function Mixed Lymphocyte Culture Peripheral Mononuclear Cell Cell Surface Structure Cell Cytolysis
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