Heterogeneity of Inhibition of Cytolytic T Lymphocyte Clones by Monoclonal Anti-Lyt-2/3 Antibodies: Parallel Effects on Cytolysis, Proliferation and Lymphokine Secretion
The interaction between cytolytic T lymphocytes (CTL) and target cells is presumed to be mediated by antigen-specific receptors on the surface of CTL. One approach to the identification and characterization of such putative receptors is thus to make antisera (or monoclonal antibodies) against CTL and test these reagents for their ability to block cytolytic function. At the present time, only antibodies directed against the Lyt-2/3 antigenic complex (1, 2) or against the LFA-1 surface antigen (3) have been found to consistently inhibit CTL function in the mouse. In both instances, however, the observed inhibition is independent of the immunological specificity of the CTL. Thus, it is unlikely that either of these surface structures correspond to the CTL antigen receptor (although models in which they contribute to a constant portion of such a receptor cannot be excluded).
KeywordsSpleen Cell Cytolytic Activity Lymphocyte Clone Cytolytic Function Immunological Specificity
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