Activated Macrophage Mediated Cytotoxicity for Transformed Target Cells
The biochemical mechanisms that induce target cell lysis in cell mediated cytotoxicity systems—cytotoxic T-lymphocytes, natural killer cells, natural cytotoxicity cells, antibody dependent cell mediated cytotoxicity systems, and cytotoxic activated macrophages—are unknown. Identification of the biochemical effector mechanism(s) utilized by activated macrophages to induce stasis and lysis of transformed target cells is complicated by the large armamentarium of potential cytotoxic effector molecules that can be elaborated by macrophages. Evidence of activated macrophage mediated target cell cytotoxicity-cytostasis and cytolysis—has been observed and documented most extensively with techniques suitable for analysis of biologic phenomena at the cellular level. Observation at the cellular level has not provided evidence that demonstrates, in a definitive way, which potential effector molecules, among the many elaborated by macrophages, are relevant to the destruction of nucleated mammalian cells or to control of abnormal proliferation of mammalian cells in vivo.
KeywordsTarget Cell L1210 Cell Mitochondrial Respiration Terminal Electron Acceptor Mycobacterium Bovis
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