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Mechanisms of Macrophage-Mediated Tumor Cytolysis

  • M. E. Key
  • L. Hoyer
  • C. Bucana
  • M. G. HannaJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)

Abstract

Important roles have been proposed for both cellular (1,2) and humoral (3–5) immunity in the complex host reaction to neoplastic growth. Killing of syngeneic tumor cells, at least in vitro, can be mediated by many different host cell types either alone or in combination with humoral factors. The mechanisms of tumor cell destruction by macrophages in particular have been studied extensively because of the known tumoricidal properties of macrophages (6–8) and the histological observation that these cells are capable of infiltrating various solid tumors in several different species (9).

Keywords

Bacillus Calmette Guerin Dextran Sulfate Tumor Cell Killing Tumor Cell Surface Muramyl Dipeptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • M. E. Key
    • 1
  • L. Hoyer
    • 1
  • C. Bucana
    • 1
  • M. G. HannaJr.
    • 1
  1. 1.Cancer Metastasis and Treatment Laboratory, Cancer Research FacilityNCI-FrederickFrederickUSA

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