Influence of Monovalent Cation Concentrations on Monocyte-Mediated ADCC

  • Stephan Ladisch
  • Lisa Ulsh
  • Stephen A. Feig
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


Studies of effector cell biochemical processes associated with cell-mediated cytolysis have been undertaken by numerous laboratories to define the conditions required for the expression of cytolytic activity, and hopefully to ultimately eludicate mechanisms of cytolysis. By such studies, the requirements for the divalent cations, Ca++ and/or Mg++, in T-cell and non-T cell-mediated cytolysis have been demonstrated using chelating agents (1,2). Similar studies of the possible importance of the monovalent cations, Na+ and K+, had been impeded by lack of equally selective means of altering their intracellular concentrations. However, inhibition of cytolytic activity by ouabain (3,4). which specifically blocks membrane active transport of Na+ and K+ (5), indicates that these cations as well may influence cytolytic activity.


Active Transport Effector Cell Potassium Concentration Cation Concentration Monovalent Cation 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Stephan Ladisch
    • 1
  • Lisa Ulsh
    • 1
  • Stephen A. Feig
    • 1
  1. 1.Division of Hematology/Oncology and Gwynne Hazen Cherny Memorial Laboratories Dept. of PediatricsUCLA School of MedicineLos AngelesUSA

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