Associative Recognition in ADCC

  • Peter Perlmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 146)


In ADCC, recognition of the target cells is mediated by IgG antibodies. Available evidence also suggests that target cell lysis is triggered by the interaction of Fc structures of the inducing IgG with the Fcγ-receptors of the killer cell (1). Target cell recognition and triggering of lysis would thus appear to be linked but independent reactions. In the following I will discuss some additional recognition phenomena which are independent of the inducing antibody but which nevertheless are important in regulating killer cell — target cell interaction ADCC. We call this “associative recognition” and I will discuss four examples, three from our own work and one from the work of others.


Target Cell Sheep Erythrocyte Helix Pomatia Associative Recognition Mumps Virion 


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Peter Perlmann
    • 1
  1. 1.Wenner-Gren InstituteUniversity of Stockholm45 StockholmSweden

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