Associative Recognition in ADCC
In ADCC, recognition of the target cells is mediated by IgG antibodies. Available evidence also suggests that target cell lysis is triggered by the interaction of Fc structures of the inducing IgG with the Fcγ-receptors of the killer cell (1). Target cell recognition and triggering of lysis would thus appear to be linked but independent reactions. In the following I will discuss some additional recognition phenomena which are independent of the inducing antibody but which nevertheless are important in regulating killer cell — target cell interaction ADCC. We call this “associative recognition” and I will discuss four examples, three from our own work and one from the work of others.
KeywordsTarget Cell Sheep Erythrocyte Helix Pomatia Associative Recognition Mumps Virion
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