The Differences in Receptor Cross Reactivity and Clonal Structure Between Cytotoxic T Lymphocytes, Specific Suppressor T Cells and Memory T Cells Immune to Antigens of the H-2 Complex
Study of the T lymphocyte clonal structure is complicated by striking inhomogeneity of T cells responding to the same antigen. T cells are shown to perform various functions; killer, suppressor, helper, delayed hypersensitivity reactions. The relevant T cell subsets appear not to be identical as to the structure of their antigen-binding receptors (l). Moreover, effector T cell receptor contact with an antigen, in addition to providing antigenic recognition, simultaneously promotes triggering of the specific T cell function, particularly the killer activity of cytotoxic T lymiphocytes (CTL)(2,3). As other T cell subsets responding to the same H-2 antigen are unable to lyse target cells (TC), it remains unclear in what way the specific T cell function is due to peculiarities of the determinant recognizable by the relevant receptors. In other words, what is the property of the determinant, recognition of which leads to activation of the CTL function.
KeywordsMixed Lymphocyte Reaction Delay Hypersensitivity Reaction Clonal Structure Inhibition Index Cytotoxic Index
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