Mixed Connective Tissue Disease and Renal Disease
Mixed connective tissue disease (MCTD) was described in 1972 by Sharp et al (1) as a syndrome of overlapping features of systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), and myositis. The serum of MCTD patients characteristically contained high titers of antibody to nuclear ribonucleoprotein (RNP) (2,3). While the initial report stressed the paucity of renal involvement in MCTD, subsequent studies of adults (4–13) and children (14–18) noted a higher prevalence of nephropathy (10–50%).
KeywordsSystemic Lupus Erythematosus Nephrotic Syndrome Renal Involvement Membranous Nephropathy Aseptic Meningitis
Unable to display preview. Download preview PDF.
- 4.Hence PK, Edgington TS, Tan EM: The evolving clinical spectrum of mixed connective tissue disease (MCTD). Arthritis Rheum 18:404, 1975 (abstr).Google Scholar
- 11.Silverstein R, Vergne-Marini P: The kidney in mixed connective tissue disease and Sjorgen’s syndrome, in Suki WN, Eknoyan G (eds): The Kidney in Systemic Disease (ed 2). New York, Wiley & Sons, 1981, pp 77–97.Google Scholar
- 16.Mundy TM, Landing BH, Hanson V, et al: Renal involvement in mixed connective tissue disease in childhood. Arthritis Rheum 23:724, 1980 (abstr).Google Scholar
- 17.Baldassare A, Weiss T, Auclair R, et al: Mixed connective tissue disease (MCTD) in childhood. Arthritis Rheum 19:788, 1976 (abstr).Google Scholar
- 19.Guit GL, Shaw PC, Ehrlich J, Kroon HM, Oudkerk M: Mediastinal lymphadenopathy and pulmonary arterial hyperteinsion in pulmonary arterial hypertension in mixed connective tissue disease. Radiology 154:305–306, 1980.Google Scholar
- 25.Germain MJ, Davidman M: Pulmonary hemorrhage and acute renal failure in a patient with mixed connective tissue disease. Am J Kidney Dis III:420–424, 1984.Google Scholar
- 30.Bennett RM, Spargo BH: Immune complex nephropathy in mixed connective tissue disease. 63:534–541, 1977.Google Scholar