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Mixed Connective Tissue Disease and Renal Disease

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Drugs, Systemic Diseases, and the Kidney

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 252))

Abstract

Mixed connective tissue disease (MCTD) was described in 1972 by Sharp et al (1) as a syndrome of overlapping features of systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), and myositis. The serum of MCTD patients characteristically contained high titers of antibody to nuclear ribonucleoprotein (RNP) (2,3). While the initial report stressed the paucity of renal involvement in MCTD, subsequent studies of adults (4–13) and children (14–18) noted a higher prevalence of nephropathy (10–50%).

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Authors and Affiliations

  1. University of Southern California School of Medicine, 2025 Zonal Ave., 90033, Los Angeles, CA, USA

    Mohammad Akmal

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  1. Mohammad Akmal
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Editors and Affiliations

  1. University of Bari, Bari, Italy

    Alberto Amerio  & Pasquale Coratelli  & 

  2. University of Southern California, Los Angeles, California, USA

    Vito M. Campese  & Shaul G. Massry  & 

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© 1989 Plenum Press, New York

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Akmal, M. (1989). Mixed Connective Tissue Disease and Renal Disease. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_5

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  • DOI: https://doi.org/10.1007/978-1-4684-8953-8_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8955-2

  • Online ISBN: 978-1-4684-8953-8

  • eBook Packages: Springer Book Archive

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