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Mixed Connective Tissue Disease and Renal Disease

  • Mohammad Akmal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)

Abstract

Mixed connective tissue disease (MCTD) was described in 1972 by Sharp et al (1) as a syndrome of overlapping features of systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), and myositis. The serum of MCTD patients characteristically contained high titers of antibody to nuclear ribonucleoprotein (RNP) (2,3). While the initial report stressed the paucity of renal involvement in MCTD, subsequent studies of adults (4–13) and children (14–18) noted a higher prevalence of nephropathy (10–50%).

Keywords

Systemic Lupus Erythematosus Nephrotic Syndrome Renal Involvement Membranous Nephropathy Aseptic Meningitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Mohammad Akmal
    • 1
  1. 1.University of Southern California School of MedicineLos AngelesUSA

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