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Effect of Imidazole 2-Hydroxybenzoate on Erythrocyte Charge: A Possible Explanation of its Hypoalbuminuric Action

  • G. Gambaro
  • E. Cicerello
  • S. Mastrosimone
  • D. Del Prete
  • T. Lavagnini
  • C. Briani
  • B. Baggio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)

Abstract

Recently in insulin-dependent diabetic (IDD) patients with incipient nephropathy we observed that a new non-steroidal anti-inflammatory drug (NSAID), Imidazole 2-hydroxybenzoate (ITF-182). induced a reduction of the urinary albumin excretion rate (1). Since this drug did not determine any significant variation of blood pressure and of glomerular filtration rate, we suggested the hypothesis that this drug exerted its hypoalbuminuric effect modifying the glomerular charge permeaselectivity similarly to other NSAIDs (2), instead of acting on intrarenal hemodynamic.

Keywords

Nephrotic Syndrome Alcian Blue Electrostatic Charge Urinary Albumin Excretion Rate Urinary Excretion Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    B. Baggio, C. Briani, E. Cicerello et at Effects of imidazole 2-hydroxybenzoate on glycosaminoglycan and albumin urinary excretion in type 1 diabetic patients. Nephron (in press).Google Scholar
  2. 2.
    R. Vriesendorp, A. J. M. Donker, D.de Zeeuw et al Effects of non steroidal anti-inflammatory drugs on proteinuria. Am J Med 81 (s2B): 84 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    R. Arumugham, S. M. Bose. Effect of indomethacin and naproxen on the metabolism of glycosaminoglycans. Scand J Rheumatol 11: 225 (1980).CrossRefGoogle Scholar
  4. 4.
    C. Gambaro, B. Baggio, E. Cicerello et al Abnormal erythrocyte charge in diabetes mellitus. Link with microalbuminuria. Diabetes (in press).Google Scholar
  5. 5.
    M. Levin, C. Smith, M. D. S. Walters et al Steroid-responsive nephrotic syndrome: a generalized disorder of membrane negative charge. Lancet 2: 239 (1985).PubMedCrossRefGoogle Scholar
  6. 6.
    J. M. Boulton-Jones, C. McWilliams, L. Chandrachud. Variation in charge on red cells of patients with different glomerulopathies. Lancet 2: 186 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    T. Deckert, B. Feldt-Rasmussen, E. Mathiesen et al Pathogenesis of incipient nephropathy: a hypothesis. Diabetic Nephrop 2: 83 (1985).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • G. Gambaro
    • 1
  • E. Cicerello
    • 1
  • S. Mastrosimone
    • 1
  • D. Del Prete
    • 1
  • T. Lavagnini
    • 1
  • C. Briani
    • 1
  • B. Baggio
    • 1
  1. 1.Institute of Internal Medicine, Institute of Metabolic DiseasesUniversity Hospital, University of PadovaPadovaItaly

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