Abstract
Rhabdomyolysis describes the damage of striated muscle cell membranes which leads to fluid and electrolyte imbalances and to liberation of muscle components. The causes leading to rhabdomyolysis are numerous. The renal tubular overload with myoglobin can induce acute renal failure. The acute myoglobinuric renal failure in patients with crush- syndrome has been known since the first description by Bywaters and Beall (1941). This description gave rise to numerous reports on cases of acute renal insufficiency after traumatic or nontraumatic rhabdomyolysis. In about 8-20% of patients with rhabdomyolysis an acute myoglobinuric renal failure is observed. Myoglobinemia, toxic muscle cell membrane components, and alteration of renal perfusion lead to acute tubular necrosis. Circulatory collapse and shock represent additional factors in the pathogenesis of the acute renal failure (Bogaerts et al., 1982; Colombo et al., 1985; Grossmann et al., 1974; Hamilton et al, 1971; Hamilton et al., 1972; Kathrein et al., 1983; Koffler et al., 1976; Rowland and Penn, 1972; Sidorara et al., 1985). The usual therapy consists of adjustment of volume depletion and balancing of acid-base-electrolyte metabolism.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literature
Akmal, M., Goldstein, D. A., Telker, N., Wilkinson, E., Masory, S.G., 1978, Resolution of Muscle Calcification in Rhabdomyolysis and Acute Renal Failure, Ann.intern.Med., 89:928
Ayer, G., Grandchamp, A., Wyler, T,, Truniger, B., 1971, Intrarenal hemodynamics in glycerol-indurced myohemoglobinuric acute renal failure in the rat, Circulat, Res, 24:128
Bogaerts, Y., Lameire, N., Ringoir, S., 1982, The compart mental syndrome: a serious complication of acute rhabdomyolysis, Clin,Nephrol,, 17:206
Bywaters, E. G,, Beall, D., 1941, Crush injuries with impairment of renal function,, Brit.med.J., 1:427
Colombo, A., Briner, V., Truniger, B., 1985, Rhabdomyolyse, Dtsch, Med, Wschr., 110:1461
Glassock, R. J., 1983, Hematuria and Pigmenturia, in: Textbook of Nephrology, S. G. Massry, R. J. Glassock, ed,, Williams and Wilkins, Baltimore/London
Grossmann, R. A., Hamilton, R. W., Morse, B. M., Penn, A. S., Goldberg, M., 1974, Nontraumatic rhabdomyolysis and acute renal failure. New Engl.J.Med., 291:807
Hamilton, L. L., Ramsey, W. H., 1971, Acute myoglobinuria associated with heroin addiction, J.Amer.med.Ass., 291:1172
Hamilton, R. W., Gardner, L. B., Penn, A. S., et al., 1972, Acute tubular necrosis caused by exercise-induced myoglobinuria, Ann.intern.Med., 77:72
Hart, P. M., Feinfeld, D. A., Briscoe, A. M., Nurese, H. M., Hotchkiss, J. L., Thomson, G. E., 1982, The effect of renal failure and hemodialysis on serum and urine myoglobin, Clin. Nephrol., 18:141
Kathrein, H., Kirchmair, W., König, P., v.Dittrich, P., 1983, Rhabdomyolyse mit akutem Nierenversagen nach Heroinintoxikation, Dtsch.Med.,Wschr., 108:464
Koffler, A., Friedler, R. M., Massry, S. G., 1976, Acute renal failure due to non-traumatic rhabdomyolysis, Ann.intern.Med. 85:23
Llach, F. A., Felsenfeld, A. J., Haussler, M. R., 1981, The Pathophysiology of altered calcium metabolism in rhabdomyolysis-induced acute renal failure. New.Engl.J.Med., 305:117
Massry, S. G., 1984, Rhabdomyolysis: a clinical entity for the study of role of proteases, Adr.Exp.Med.Biol., 167:581
McCarron, D. A., Elliott, W. C., Rose, J. S., Bennett, W. M., 1979, Severe mixed metabolic acidosis secondary to rhabdomyolysis, Amer,J.Med., 67:905
Oken, D. E., DiBona, G. F., McDonald, F. D.,1970, Micropuncture studies of the recovery phase of myohemoglobinuric acute renal failure in the rat, J.Clin.Invest., 49:730
Richter, R. W., Chellenor, Y. B., Pearson, J., Kagen, L. J., Hamilton, L. L., Ramsey, W. H,, 1971, Acute myoglobinuria associated with heroin addiction, J.Amer.med.Ass., 17:1172
Rowland, L. P., Penn, A. S., Myoglobinuria., Med.din.N. Amer., 56:1233
Rumpf, K. W., Kaiser, H., Leschke, M., Scheler, F., 1983, Diagnostik bei Myoglobinurie, Dtsch.med.Wschr., 108:266
Sidorara, D. D., Ierusalimskaia, L. A., Valentik, M. F, Razenko, T. N., Bedikhin, A. V., 1985, Porazhenie pochek pri alimentarno - toksicheskoi paroksizmal’noi mioglobinurii, (luksovsko-Sartlanskoi bolezni), Ter.Arkh., 57:120
Thomas, M. A. B., Ibels, L. S., 1984, Rhabdomyolysis acute renal failure (RMARF), Kidney Int., 26:241
Winterberg, B., Tenschert, W., Niederlein, G., Rolf, N., Ramme, K., Wendt, M., Lison, A. E., Zumkley, H., 1987, Akutes myoglobinurisches Nierenversagen, Fortschr.Med., 105:689
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Winterberg, B. et al. (1989). Cavh in Myorenal Syndrome. In: Amerio, A., Coratelli, P., Campese, V.M., Massry, S.G. (eds) Drugs, Systemic Diseases, and the Kidney. Advances in Experimental Medicine and Biology, vol 252. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8953-8_40
Download citation
DOI: https://doi.org/10.1007/978-1-4684-8953-8_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-8955-2
Online ISBN: 978-1-4684-8953-8
eBook Packages: Springer Book Archive