Oxalate Deposits in the Kidney of 5/6 Nephrectomised Rats Supplemented by Large Doses of Vitamin C

  • Keiji Ono
  • Hiroko Ono
  • Yohko Hisasue
  • Kazuhiko Kikawa
  • Yukinori Oh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)


The secondary oxalosis of renal failure has been recognised for more than 20 years (Bennett and Rosenblum, 1961), but details of its prevalence and clinical features have been addressed only recently(Salyer and Keren, 1973; Boer et al., 1984; Pru et al., 1985). Oxalate is a non-metabolisable end product of glycine and ascorbic acid metabolism(Elder and Wyngaarden, 1960) and virtually all of it is excreted by the kidneys. Renal insufficiency can produce oxalate loads that exceed renal excretory capacity. Protein binding of oxalate is minimal and most of it should be removed by hemodialysis. However, hemodialysis does not remove oxalate as fast as it is formed, leaving patients at risk from the complications which result from systemic oxalosis (Landwehr et al., 1987).


Oxalic Acid Urinary Oxalate Calcium Oxalate Crystal Remnant Kidney Plasma Oxalate 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Keiji Ono
    • 1
  • Hiroko Ono
    • 1
  • Yohko Hisasue
    • 1
  • Kazuhiko Kikawa
    • 2
  • Yukinori Oh
    • 3
  1. 1.Ono Geka ClinicFukuokaJapan
  2. 2.Fukuoka Tokushukai HospitalFukuokaJapan
  3. 3.Fukuoka Red Cross HospitalFukuokaJapan

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