Characterization of Bilateral Renal Response to Atrial Natriuretic Peptide in 2-Kidney, 1 Clip Hypertensive Rats

  • Wann-Chu Huang
  • Jian-Nan Wu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)


The atrial natriuretic peptide (ANP) released from the cardiocytes of mammalian atria has been implicated in the regulation of blood pressure and body fluid balance1,2. Previous studies have shown that this peptide can produce vasodepressor effect through a direct arterial vasodilation or reduced cardiac output and attenuation of endogenous vasoconstrictors2–5. Also, it can induce a striking natriuretic and diuretic effect by changing the renal hemodynamics and tubular functionl,2,6,7. The hypotensive and renal effects of ANP may be prominent in conditions with elevated activity of the renin-angiotensin system7–9.


Glomerular Filtration Rate Atrial Natriuretic Peptide Atrial Natriuretic Factor Contralateral Kidney Excretory Function 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Wann-Chu Huang
    • 1
  • Jian-Nan Wu
    • 1
  1. 1.Department of Physiology and BiophysicsNational Defense Medical CenterTaipeiTaiwan, Republic of China

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