Thrombotic Microangiopathy in Lupus Nephritis
Renal involvement in Systemic Lupus Erythematosus (SLE) mainly consists of inflammatory glomerular lesions, possibly due to immune-complex deposition. A considerable number of microscopic vascular changes related to an immune-complex pathogenesis have also been identified: necrotizing arteritis and arteriolitis, with or without fibrinoid necrosis, mucinous and/or onion-skin intimal thickening (1,2), More recently, several lines of evidence have indicated the importance of coagulation mechanisms and of platelets as mediators of glomerular injury in SLE (3,4,5). Nonetheless, the picture of “pure” thrombotic microangiopathy is very rare in SLE (6,7).
KeywordsSystemic Lupus Erythematosus Lupus Nephritis Thrombotic Microangiopathy Glomerular Injury Crescentic Glomerulonephritis
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