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Thrombotic Microangiopathy in Lupus Nephritis

  • M. T. Porri
  • M. I. Quareghi
  • F. Ferrario
  • G. Colasanti
  • R. Rossi
  • E. Schiaffio
  • G. Toia
  • G. D’Amico
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)

Abstract

Renal involvement in Systemic Lupus Erythematosus (SLE) mainly consists of inflammatory glomerular lesions, possibly due to immune-complex deposition. A considerable number of microscopic vascular changes related to an immune-complex pathogenesis have also been identified: necrotizing arteritis and arteriolitis, with or without fibrinoid necrosis, mucinous and/or onion-skin intimal thickening (1,2), More recently, several lines of evidence have indicated the importance of coagulation mechanisms and of platelets as mediators of glomerular injury in SLE (3,4,5). Nonetheless, the picture of “pure” thrombotic microangiopathy is very rare in SLE (6,7).

Keywords

Systemic Lupus Erythematosus Lupus Nephritis Thrombotic Microangiopathy Glomerular Injury Crescentic Glomerulonephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • M. T. Porri
    • 1
  • M. I. Quareghi
    • 3
  • F. Ferrario
    • 1
  • G. Colasanti
    • 1
  • R. Rossi
    • 3
  • E. Schiaffio
    • 2
  • G. Toia
    • 2
  • G. D’Amico
    • 1
  1. 1.Dept. of NephrologyS. Carlo Hosp.MilanoItaly
  2. 2.Dept. of pathologyS. Carlo HospMilanoItaly
  3. 3.Dept. of NephrologyS. Anna Hosp.ComoItaly

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