Aminoglycoside Nephrotoxicity: Mechanism and Prevention

  • Marc E. De Broe
  • Rubén A. Giuliano
  • Gert A. Verpooten
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)


Nephrotoxicity limits the clinical utility of aminoglycosides (Lietman, 1985). Therefore, the identification of factors associated with a greater incidence of renal damage is critical. These factors can be classified in those related to the drug and its administration and those related to the clinical condition of the patient (Table 1).


Proximal Tubular Cell Renal Uptake Renal Handling Cortical Uptake Aminoglycoside Nephrotoxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Marc E. De Broe
    • 1
  • Rubén A. Giuliano
    • 1
  • Gert A. Verpooten
    • 1
  1. 1.Department of Nephrology-HypertensionUniversity Hospital AntwerpenAntwerpenBelgium

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