The Analgesic Agents and Renal Disease

  • Sandra Sabatini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)


In 1827 the active ingredient in willow bark, an extract useful to the ancients for analgesia, was found to contain a precursor of salicylic acid (salicin) (l). In 1899 Dreser synthesized aspirin (acetylsalicylic acid), and since that time numerous congeners have been introduced into clinical medicine (1, 2). These include phenacetin, acetanilid, and acetaminophen. In the 1960’s, a new series of compounds was introduced, the nonsteroidal anti-inflammatory agents. Some of these are chemically related to acetanilid (i.e., phenylbutazone and indomethacin), while others are not (i.e., meclofenamate, Ibuprofen, and Piroxicam). Many compounds have been screened in the laboratory, and virtually all have anti-inflammatory, antipyretic, and analgesic effects similar to those of the salicylates. The compounds inhibit the biosynthesis of prostaglandins in many tissues, including the kidney, and it is thought that this inhibition is the mechanism whereby they exert their analgesic effects (3).


Papillary Necrosis Analgesic Nephropathy Renal Papillary Necrosis Salt Wastage Magnesium Excretion 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Sandra Sabatini
    • 1
  1. 1.Departments of Internal Medicine and PhysiologyTexas Tech University Health Sciences CenterLubbockUSA

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