Pre-Eclampsia as a Multi-System Disease

  • John M. Davison
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 252)


Hypertension complicates 1 in 10 pregnancies. Approximately 50–60% of these women have pre-eclampsia, which occurs primarily in first pregnancies, usually after the twentieth gestational week and most often near term. of the various systemic changes in pre-eclampsia, hypertension, oedema and proteinuria have been given significant status for the purpose of definition.1 Indeed, other clinical labels include pregnancy-induced hypertension(PIH), hypertension peculiar to pregnancy and pregnancy associated hypertension, perhaps mistakenly reflecting the exclusive importance of raised blood pressure (BP). Hypertension, oedema and proteinuria are merely conveniently accessible clinical signs which are not specific or characteristic of the disorder but secondary features of whatever comprises the primary pathology. Furthermore, in clinical terms, there is difficulty distinguishing between pre-eclampsia, essential or secondary hypertension, renal disease or combinations of these entities. 2


Obstet Gynecol Normal Pregnancy Spiral Artery Hypertensive Encephalopathy Renal Haemodynamics 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • John M. Davison
    • 1
  1. 1.Medical Research Council Human Reproduction GroupPrincess Mary Maternity HospitalNewcastle upon TyneEngland

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