The Immunology of Glomerular Nephropathies

  • B. Van Damme
  • V. J. Desmet
Part of the Ettore Majorana International Science Series book series (EMISS, volume 9)


Immunological damage is a frequent cause of glomerulonephritis. This can be related to antibodies against glomerular basement membrane antigens or to the deposition or the in situ formation of immune complexes in the glomerulus. Depending on the localisation and the severity of the aggression different degrees of inflammation occur. Adaptation of the mesangium or of the visceral epithelium results in intracapillary proliferation and membranous transformation respectively, while breaks in the glomerular capillary wall result in crescent formation.


Immune Complex Glomerular Basement Membrane Crescent Formation Glomerular Damage Membranous Glomerulonephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Anand, S.K., Landing, B.K., Heuser, E.T., Olson, D.L., Grushkin, C.M. and Lieberman, E.: Changes in glomerular basement membrane antigen(s) with age. J. Pediat. 92: 952, (1978).CrossRefGoogle Scholar
  2. 2.
    Arakawa, M. and Kimmelstiel, P.: Circumferential mesangial interposition. Lab. Invest. 21: 276, (1969).Google Scholar
  3. 3.
    Arend, W.P. and Mannik, M.: Studies on antigen-antibody complexes. II. Quantification of tissue uptake of soluble complexes in normal and complement depleted rabbits. J. Immunol 107: 63, (1971).Google Scholar
  4. 4.
    Atkins, R.C., Holdsworth, S.R., Glasgow, E.F. and Matthews, F.E.: The macrophage in human rapidly progressive glomerulonephritis. Lancet 1: 830, (1976).CrossRefGoogle Scholar
  5. 5.
    Blantz, R.C., Tucker, B.J. and Wilson, C.B.: The acute effects of anti-glomerular basement membrane antibody upon glomerular filtration in the rat. The influence of dose and complement depletion. J. Clin. Invest. 61: 910, (1978).CrossRefGoogle Scholar
  6. 6.
    Bretten, R. and Bariety, J.: A comparative ultrastructural localization of concanavalin A, wheat germ and ricinus communis on glomeruli of normal rat kidney. J. Histochem. Cytochem. 24: 1093, (1976).CrossRefGoogle Scholar
  7. 7.
    Cochrane, Ch., Unanue, E.R. and Dixon, F.J.: A role of polymorphonuclear leukocytes and complement in nephrotoxic nephritis. J. Exp. Med. 122: 99, (1965).CrossRefGoogle Scholar
  8. 8.
    Couser, W.G., Steinmuller, D.R., Stilplant, M.M., Salant, D.J. and Lowenstein, L.M.: Experimental glomerulonephritis in the isolated perfused rat kidney. J. Clin. Invest. 62: 1275, (1978).CrossRefGoogle Scholar
  9. 9.
    Dixon, F.J., Feldman, J.D. and Vazquez, J.J.: Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J. Exp. Med. 113: 899, (1961).CrossRefGoogle Scholar
  10. 10.
    Ehrenreich, T. and Churg, J.: Pathology of membranous nephropathy. Path. Annual 3: 145, (1968).Google Scholar
  11. 11.
    Es, L.A., Blok, A.P.R., Schoenfeld, L. and Glassock, R.J.: Chronic nephritis induced by antibodies reacting with glomerular bound immune complexes. Kidney Int. 11: 106, (1977).CrossRefGoogle Scholar
  12. 12.
    Evans, D.J.: Pathogenesis of membranous glomerulonephritis. Lancet 1: 1143, (1974).CrossRefGoogle Scholar
  13. 13.
    Feenstra, K., Lee, R.V.D., Greben, H.A., Arends, A. and Hoede- maeker. Ph.J.: Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level. Lab. Invest. 32: 235, (1975).Google Scholar
  14. 14.
    Fleuren, G.J., Grond, J. and Hoedemaeker, Ph. J.: The pathogenetic role of recirculating antibody in autologous immune complex glomerulonephritis. Clin. Exp. Immunol. 41: in press (1980).Google Scholar
  15. 15.
    Fleuren, G.J., Grond, J. and Hoedemaeker, Ph. J.: In situ formation of subepithelial glomerular immune complexes in passive serum sickness. Kidney Int. 17: in press (1980).Google Scholar
  16. 16.
    Fleuren, G.J.: Personal communication (1980).Google Scholar
  17. 17.
    Foidart-Willems, J., Dechenne, Ch. and Mahieu, Ph.: Biosynthesis of basement membrane collagen in cultures of renal glomerular and tubular epithelial cells. Diabète et Métabolisme 1: 227, (1975).Google Scholar
  18. 18.
    Germuth, F.G. and Rodriguez, E.: Immunopathology of the renal glomerulus. Immune complex deposit and antibasement membrane disease (Little & Brown, Boston 1973).Google Scholar
  19. 19.
    Golbus, S.M. and Wilson, C.B.: Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capillary wall. Kidney Int. 16: 148, (1979).CrossRefGoogle Scholar
  20. 20.
    Hakenstaad, A.O. and Mannik, M.: Saturation of the reticuloendothelial system with soluble immune complexes. J. Immunol. 112: 1939, (1974).Google Scholar
  21. 21.
    Kanwar, Y.S. and Farquhar, M.G.: Anionic sites in the glomerular basement membrane. In vivo and in vitro localization to the laminae rarae by cationic probes. J. Cell Biol. 81: 137, (1979).CrossRefGoogle Scholar
  22. 22.
    Keane, W.F.: Impaired mesangial cleaning of macromolecules in chronic mesangial immune complex injury. Kidney Int. 16: 784, (1979).Google Scholar
  23. 23.
    Kondo, Y., Shigematsu, H. and Kobayashi, Y.: Cellular aspects of rabbit Masugi nephritis. II. Progressive glomerular injuries with crescent formation. Lab. Invest. 27: 620, (1972).Google Scholar
  24. 24.
    Koyama, A., Niwa, Y., Shigematsu, H., Taniguchi, M. and Tada, T.: Studies on passive serum sickness. II. Factors determining’the localization of antigen-antibody complexes in the murine renal glomerulus. Lab. Invest. 38: 253, (1978).Google Scholar
  25. 25.
    Kylstra, A., Lely, A., Knutson, D.W., Fleuren, G.J. and Es, L.A.: The influence of phagocyte function on glomerular localization of aggregated IgM in rats. Clin. Exp. Immunol. 32: 207, (1978).Google Scholar
  26. 26.
    Mannik, M. and Haakenstad, A.O.: Circulation and glomerular deposition of immune complexes. Arthritis Rheum. 20: 148, (1977).Google Scholar
  27. 27.
    Mauer, S.M., Sutherland, D.E.R., Howard, R.J., Fish, A.J., Najarian, J.S. and Michael, A.F.: The glomerular mesangium. III. Acute immune mesangial injury: a new model of glomerulonephritis. J. Exp. Med. 137: 553, (1973).CrossRefGoogle Scholar
  28. 28.
    McCoy, R.C., Johnson, H.K., Stone, W.J. and Wilson, C.B.: Variation in glomerular basement membrane antigens in heriditary nephritis. Lab. Invest. 34: 325, (1976).Google Scholar
  29. 29.
    Michael, A.F., Nevins, T.E., Raij, L., Keane, W.F. and Scheinman, J.I.: Macromolecular transport in the glomerulus: studies of the mesangium and epithelium in vivo and in vitro. In: Immunologic mechanisms of renal disease. C.B. Wilson, B.M. Brenner, J.H. Stein (eds.). (Churchill-Livingstone, London 1979).Google Scholar
  30. 30.
    Miyakawa, Y., Kitamura, K., Shibata, S. and Naruse, T.: Demonstration of human nephritogenic tubular antigen in the serum and organs by radioimmunoassay. J. Immunol. 117: 1203, (1976).Google Scholar
  31. 31.
    Naruse, T., Kitamura, K., Miyakawa, Y. and Shibata, S.: Deposition of renal tubular epithelial antigen along the glomerular capillary walls of patients with membranous glomerulonephritis. J. Immunol. 110: 1163, (1973).Google Scholar
  32. 32.
    Pirani, C.L. and Silva, F.G.: The kidneys in systemic lupus erythematosus and other collagen diseases: recent progress. In: Kidney disease: present status. International Academy of Pathology Monograph. J. Churg, B.H. Spargo, F.K. Mostofi, M.R. Abell (eds.) Williams & Wilkins Co., Baltimore (1979).Google Scholar
  33. 33.
    Rothbard, S. and Watson, R.F.: Renal glomerular lesions induced by rabbit anti rat collagen serum in rats prepared with adjuvant. J. Exp. Med. 109: 633, (1959).CrossRefGoogle Scholar
  34. 34.
    Ryan, G.B., Hein, S.J. and Karnovsky, M.J.: Glomerular permeability to proteins. Effects of hemodynamic factors on the distribution of endogenous immunoglobulin G and exogenous catalase in the rat glomerulus. Lab. Invest. 34: 415, (1976).Google Scholar
  35. 35.
    Ryan, G.B. and Mayno, G.: Acute inflammation, a review. Am. J. Path. 86: 185 (1977).Google Scholar
  36. 36.
    Scheinman, J.I., Brown, D. and Michael, A.F.: Collagen synthesis by human glomerular cells in culture. Biochim. Biophys. Acta 542: 128, (1978).CrossRefGoogle Scholar
  37. 37.
    Segoloni, G., Camussi, G., Ragni, R., Stratta, P., Piccoli, G. and Vercellone, A.: Kinetics of glomerular deposition of immune complexes in rabbit acute serum nephritis. Kidney Int. 11: 148, (1977).Google Scholar
  38. 38.
    Shimizu, F., Mossman, H., Takamiya, H. and Vogt, A. Effect of antibody avidity on the induction of renal injury in anti- glomerular basement membrane nephritis. Brit. J. Exp. Path. 59: 624, (1978).Google Scholar
  39. 39.
    Stejskal, J., Pirani, C.L., Okada, M., Mandalenakis, N. and Pollak, V.E.: Discontinuities (gaps) of the glomerular capillary wall and basement membrane in renal disease. Lab. Invest. 28: 149, (1973).Google Scholar
  40. 40.
    Tallqvist, G., Pasternack, A. and Törnroth, T.: Indentations of the glomerular basement membrane in renal diseases: a light and electron microscopic study on ultrathin serial sections. Lab. Invest. 35: 327, (1976).Google Scholar
  41. 41.
    Thomson, N.M., Simpson, I.J., Evans, D.J. and Peters, D.K.: Defibrination with ancrod in experimental chronic immune complex nephritis. Clin. Exp. Immunol. 20: 527, (1975).Google Scholar
  42. 42.
    Törnroth, T. and Skrifvars, B.: The development and resolution of glomerular basement membrane changes associated with subepithelial immune deposits. Am. J. Path. 79: 219, (1975).Google Scholar
  43. 43.
    Törnroth, T.: The fate of subepithelial deposits in acute poststreptococcal glomerulonephritis. Lab. Invest. 35: 461, (1976).Google Scholar
  44. 44.
    Treser, G., Semar, M., McVicar, M., Franklin, M., Ty, A., Sagel, I. and Lange, K.: Antigenic streptococcal components in acute glomerulonephritis. Science 163; 676, (1969).ADSCrossRefGoogle Scholar
  45. 45.
    Unanue, E.R. and Dixon, F.J.: Experimental glomerulonephritis. V. Studies on the interaction of nephrotoxic antibodies with tissues of the rat. J. Exp. Med. 121: 697, (1965).CrossRefGoogle Scholar
  46. 46.
    Unanue, E.R. and Dixon, F.J.: Experimental glomerulonephritis. VI. The autologous phase of nephrotoxic serum nephritis. J. Exp. Med. 121: 715, (1965).CrossRefGoogle Scholar
  47. 47.
    Van Damme, B.: Studies on mechanisms of deposition of immune complexes in experimental glomerulonephritis. Academic Thesis, Groningen. (Arscia Uitgaven, Brussels 1977).Google Scholar
  48. 48.
    Van Damme, B.J.C., Fleuren, G.J., Bakker, W.W., Hoedemaeker, P.J. and Vernier, R.L.: Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab. Invest. 38: 502, (1978).Google Scholar
  49. 49.
    Vassalli, P. and McCluskey, R.T.: The pathogenic role of the coagulation process in rabbit Masugi nephritis. Am. J. Path. 45: 653, (1964).Google Scholar
  50. 50.
    Ward, D.M., Spiegelberg, H.L. and Wilson, C.B.: Persistence of IgA aggregates in the glomerular mesangium in mice. Kidney Int. 16: 801, (1979).Google Scholar
  51. 51.
    Weening, J.J.: Mercury induced immune complex glomerulopathy. Academic Thesis, Groningen (1980).Google Scholar
  52. 52.
    Witworth, J.A., Leibowitz, S., Kennedy, M.C., Cameron, J.G., Evans, D.J., Glassock, R.J. and Schoenfeld, L.S.: Absence of glomerular renal tubular epithelial antigen in membranous glomerulonephritis. Clin. Nephrol. 5: 159, (1976).Google Scholar
  53. 53.
    Zollinger, H.U. and Mihatsch, M.J.: Renal pathology in biopsy. (Springer, Berlin 1978).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • B. Van Damme
    • 1
  • V. J. Desmet
    • 1
  1. 1.Laboratorium voor Histochemie en Cytochemie Departement Medische NavorsingKatholieke Universiteit LeuvenLeuvenBelgium

Personalised recommendations